[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Olfactory epithelium; NIH - Zebrafish Gene Collection (ZGC) project; Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
CATALYTIC ACTIVITY: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate (By similarity).
SUBCELLULAR LOCATION: Mitochondrion (Potential).
SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.

Copyright

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Cross-references

Sequence databases

EMBL

BC086742; AAH86742.1; ALT_INIT; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001008619.1; -.

UniGene

Dr.117252

3D structure databases

ModBase

Q5PRA2.

Organism-specific databases

ZFIN

ZDB-GENE-041212-44; zgc:101818.

Gene expression databases

ArrayExpress

Q5PRA2; -.

Family and domain databases

InterPro

IPR011603; 2oxoglutarate_DHase_E1.
IPR001017; DHase_E1.
IPR005475; Transketo_Cen_R.
Graphical view of domain structure.

PANTHER

PTHR23152; 2oxoglutarate_DH_E1; 1.

Pfam

PF00676; E1_dh; 1.
PF02779; Transket_pyr; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000157; Oxoglu_dh_E1; 1.

TIGRFAMs

TIGR00239; 2oxo_dh_E1; 1.

BLOCKS

Q5PRA2.

Genome annotation databases

Ensembl

ENSDARG00000016415; Danio rerio. [Contig view]

GeneID

494076; -.

KEGG

dre:494076; -.

Phylogenomic databases

HOGENOM

Q5PRA2; -.

HOVERGEN

Q5PRA2; -.

Other

ProtoNet

Q5PRA2.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Glycolysis; Mitochondrion; Oxidoreductase; Thiamine pyrophosphate; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 ?`		`Mitochondrion (Potential).`
`CHAIN`	`? 920`		`Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial.`	`PRO_0000307940`

Sequence information

Length: 920 AA [This is the length of the unprocessed precursor]

Molecular weight: 102964 Da [This is the MW of the unprocessed precursor]

CRC64: 7753F5D8CB29A2A7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLIHLPRLLH RSFGARRSFL ASLYHTQRGV YGFRPRDGPE RRAELTQISA LNRDHGLARL 

        70         80         90        100        110        120 
VEAYRAHGHK VAKINPLLPQ SPVLESVPEI SLLNGAVRGV LNTTGLRHFG KAEATAEEVV 

       130        140        150        160        170        180 
AYLESTYCGG ISVETSQLQT LEEREWFADR FEELKKEAFS PEERRMLAKL MLESQEFDHF 

       190        200        210        220        230        240 
LATKFATVKR YGGEGAESMM GFFYELFRSS VYSGVTDVVM GMPHRGRLNL LTGLLQFPPE 

       250        260        270        280        290        300 
LMFRKMRGLS EFPEHSPSIG DVLSHLTSTV ELDFGAGHPL HVTMLPNPSH LEAINPVTQG 

       310        320        330        340        350        360 
KTRGRQQVKQ DGDYSTDPHS RPGDKVICLQ VHGDASFSGQ GIVPETFTLS NLPHYRVGGS 

       370        380        390        400        410        420 
IHLIVNNQVG YTTPSERGRS SLYCSDVGKM VGCAIIHVNG DDAEEVLRAT RLAVEYQRRF 

       430        440        450        460        470        480 
RKDVIVDLLC YRQWGHNELD EPFFTNPAMY KIIRSRKSIP DSYADQLISE GLMTDEERSQ 

       490        500        510        520        530        540 
IKTSYYATLN NQLTNMTLYS PPPTNLQGRW GDLVEPQNRV SCWDTGVAQP LLQFVGAKSV 

       550        560        570        580        590        600 
DIPEEIILHS HLRKTHVQAR LQKLEEGTKL DWSTAEALAF GTLLCQGFNI RISGQDVGRG 

       610        620        630        640        650        660 
TFSQRHAMVV CQETNDMFIP LNHISSEQKG HLEVCNSALS EEAVLGFEYG MSIAQPRLLP 

       670        680        690        700        710        720 
IWEAQFGDFF NGAQIIFDTF LSGGEAKWLL QSGLVILLPH GYDGAGPEHS SCRIERFLQL 

       730        740        750        760        770        780 
CDSKEEGVDG DTVNMAVVNP TLPAQYFHLL RRQMIRNFRK PLIVASPKTL LRFSGAVSGL 

       790        800        810        820        830        840 
SDMGPGTSFK PIIGDSSVNP ASVQRVLFCS GKHYYALLKH RETIPEAEKN TALVRVEELC 

       850        860        870        880        890        900 
PFPTEALQQE LNKYTNAKEF IWSQEEPQNM GCWSFVSPRF EKQLACKLRL VSRPALPAPA 

       910        920 
VGIGTLHHQQ HEAILTSSFS

Q5PRA2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools