NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1007/s00203-004-0742-9; PubMed=15551059 [NCBI, ExPASy, EBI, Israel, Japan]
Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.;
"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1.";
Arch. Microbiol. 183:27-36(2005).

Comments

FUNCTION: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CR555306; CAI07859.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_158760.1; -.

3D structure databases

ModBase

Q5P4A4.

Enzyme and pathway databases

BioCyc

ASP76114:EBA3077-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0045020;	Biological process: error-prone DNA repair (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01902; -; 1.
PBIL [Tree]

InterPro

IPR011708; DNA_pol3_alpha.
IPR004365; NA_bd_OB_tRNA-helicase.
IPR004013; PHP_C.
IPR003141; PHP_N.
IPR004805; PolC_alpha.
Graphical view of domain structure.

Pfam

PF07733; DNA_pol3_alpha; 1.
PF02811; PHP; 1.
PF01336; tRNA_anti; 1.
Pfam graphical view of domain structure.

SMART

SM00481; POLIIIAc; 1.
SMART graphical view of domain structure.

TIGR00594; polc; 1.

Genome annotation databases

GeneID

3179816; -.

GenomeReviews

CR555306_GR; AZOSEA17340.

KEGG

eba:ebA3077; -.

NMPDR

fig|76114.4.peg.957; -.

Phylogenomic databases

HOGENOM

Q5P4A4; -.

Genome annotation databases

CMR

Q5P4A4; AZOSEA17340.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1070`	`1070`		`Error-prone DNA polymerase.`	`PRO_0000103365`

Sequence information

Length: 1070 AA [This is the length of the unprocessed precursor]

Molecular weight: 117515 Da [This is the MW of the unprocessed precursor]

CRC64: 659B91336FE4881E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDSAPPSPSP SPAPAYAELH CLTNFSFQRG ASHPEELVAR AAEAGYTALA ITDECSLAGV 

        70         80         90        100        110        120 
VRAHQQLRRL ARPLKLLIGS ELRLVDGLRV VLLATDRAAY GRLARLITIG RRAATKGRYQ 

       130        140        150        160        170        180 
LTCADLDRGI PGCLALVVPP DDRILDAAAL VADARWVGER FPDAAWLAVE LACGPDDGRR 

       190        200        210        220        230        240 
LEALLAIASA AGLPPVAATG ALMHDPSRRA LADVLAALRL RVTIAEAGRA LAPNAERALH 

       250        260        270        280        290        300 
ERAVLARRYP AELLAETLRI VARCHFRLDE LRYEYPAELV PDGETPASWL RRLVEDGLRW 

       310        320        330        340        350        360 
RHGRPQDDLA PPKVRAQVEH ELALIAELGF EAYFLTVEDL VRFARGRGIL CQGRGSAANS 

       370        380        390        400        410        420 
VICWALGITE VDPELGIMLV ERFISKERDE PPDIDVDFEH ERREEVIQYV YRKYGRERAA 

       430        440        450        460        470        480 
LAATVIRYRA RSALRDVGRA LGLPPGQLER LARDRFWFDA GRIRPERLRE AGFDPASPGV 

       490        500        510        520        530        540 
QRLATLTEAL VGFPRHLSQH VGGFVIARGR LDELVPVENA AMPERTVIQW DKDDLDALGL 

       550        560        570        580        590        600 
LKIDVLALGM LSALRRSLAL VSTWRGRPFT LADIPREAPE VYRMLSEADS IGVFQIESRA 

       610        620        630        640        650        660 
QMTMLPRLKP ARFYDLVVQV AIVRPGPIQG GMVHPYLQAR ARIERDEPVS YPQPHCPDAD 

       670        680        690        700        710        720 
ADGTCVPRPD DVRRVLERTL GVPIFQEQVM QLAVVAAGFT PGEADQLRRA MGAFRRHGEL 

       730        740        750        760        770        780 
ERYRAKLLAG MAARGYRAEF AERLCDQIEG FGSYGFPESH AASFALLVYC SAWLKCCEPA 

       790        800        810        820        830        840 
AFLCGLLNSQ PMGFYAPSQL IQDARRHGVV VLGAEVTASD WDCTLEALPD ASPGAAPAVR 

       850        860        870        880        890        900 
LGLQLVKGFG REAAMRIVAA RTERPFPNVD ELALRARLDA AALKRLAEAG ALEPLAGHRR 

       910        920        930        940        950        960 
QALWQAAAGH APEGVLRGAR IAEPRAELAA PSEAQELVAD YARLGFTLGR HPLALLRAKL 

       970        980        990       1000       1010       1020 
TTLRFVTAAE IRDYPDRKLA RIAGLVTCRQ RPGTAKGTLF LTVEDETGLA NVIVQAELVE 

      1030       1040       1050       1060       1070 
RQRREVLGAR LLGVFGQIRS KGQVVHLLAQ RLVDHSALLG ALEARSRDFQ

Q5P4A4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools