ID   DHB11_PONAB             Reviewed;         300 AA.
AC   Q5NVG2;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-NOV-2008, entry version 30.
DE   RecName: Full=Estradiol 17-beta-dehydrogenase 11;
DE            EC=1.1.1.62;
DE   AltName: Full=17-beta-hydroxysteroid dehydrogenase 11;
DE            Short=17-beta-HSD 11;
DE            Short=17betaHSD11;
DE            Short=17bHSD11;
DE   AltName: Full=17-beta-HSD XI;
DE            Short=17betaHSDXI;
DE   AltName: Full=Dehydrogenase/reductase SDR family member 8;
DE   Flags: Precursor;
GN   Name=HSD17B11; Synonyms=DHRS8;
OS   Pongo abelii (Sumatran orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Can convert androstan-3-alpha,17-beta-diol (3-alpha-
CC       diol) to androsterone in vitro, suggesting that it may participate
CC       in androgen metabolism during steroidogenesis. May act by
CC       metabolizing compounds that stimulate steroid synthesis and/or by
CC       generating metabolites that inhibit it. Has no activity toward
CC       DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione),
CC       and only a slight activity toward testosterone to A-dione (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Estradiol-17-beta + NAD(P)(+) = estrone +
CC       NAD(P)H.
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family. 17-beta-HSD 3 subfamily.
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DR   EMBL; CR926074; CAI29701.1; -; mRNA.
DR   RefSeq; NP_001127691.1; -.
DR   SMR; Q5NVG2; 30-273.
DR   GeneID; 100174773; -.
DR   HOVERGEN; Q5NVG2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002198; DHase_sc/Rdtase_SDR.
DR   InterPro; IPR002347; Glc/ribitol_DHase.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   PROSITE; PS00061; ADH_SHORT; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   Lipid synthesis; NADP; Oxidoreductase; Secreted; Signal;
KW   Steroid biosynthesis.
FT   SIGNAL        1     19       Potential.
FT   CHAIN        20    300       Estradiol 17-beta-dehydrogenase 11.
FT                                /FTId=PRO_0000031972.
FT   NP_BIND      40     64       NADP (By similarity).
FT   ACT_SITE    185    185       Proton acceptor (By similarity).
FT   BINDING     172    172       Substrate (By similarity).
SQ   SEQUENCE   300 AA;  32992 MW;  982412E8EEE44083 CRC64;
     MKFLLDVLLL LPLLIVCSLE SFVKLFIPKR RKSVTGEIVL ITGAGHGIGR LTAYEFAKLK
     SKLVLWDINK HGLEETAAKC KGLGAKVHTF VVDCSNREDI YSAAKKVKAE IGDVSILVNN
     AGVVYTSDLF ATQDPQIEKT FEVNVLAHFW TTKAFLPAMM KNNHGHIVTV ASAAGHVSVP
     FLLAYCSSKF AAVGFHKTLT DELAALQITG VKTTCLCPNF VNTGFIKNPS TSLGPTLEPE
     EVVNRLMHGI LTEQKMIFIP SSIAFLTTLE RILPERFLAV LKRKISVKFD AVIGYRMKAQ
//