EC 1.1.1.62
17-beta-hydroxysteroid dehydrogenase 11
17-beta-HSD 11
17betaHSD11
17bHSD11
17-beta-HSD XI
17betaHSDXI
Dehydrogenase/reductase SDR family member 8

Gene name

	Name:	HSD17B11
	Synonyms:	DHRS8

From

Pongo abelii (Sumatran orangutan)

[TaxID: 9601]

Taxonomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo.

Protein existence

2: Evidence at transcript level;

References

[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain cortex; The German cDNA consortium; Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione (By similarity).
CATALYTIC ACTIVITY: Estradiol-17-beta + NAD(P)⁺ = estrone + NAD(P)H.
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CR926074; CAI29701.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

Q5NVG2; 30-273.

ModBase

Q5NVG2.

Family and domain databases

InterPro

IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PRINTS

PR00081; GDHRDH.
PR00080; SDRFAMILY.

PROSITE

PS00061; ADH_SHORT; FALSE_NEG.

BLOCKS

Q5NVG2.

Phylogenomic databases

HOVERGEN

Q5NVG2; -.

Other

ProtoNet

Q5NVG2.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Lipid synthesis; NADP; Oxidoreductase; Secreted; Signal; Steroid biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 19`	`19`	`Potential.`
`CHAIN`	`20 300`	`281`	`Estradiol 17-beta-dehydrogenase 11.`	`PRO_0000031972`
`NP_BIND`	`40 64`	`25`	`NADP (By similarity).`
`ACT_SITE`	`185 185`		`Proton acceptor (By similarity).`
`BINDING`	`172 172`		`Substrate (By similarity).`

Sequence information

Length: 300 AA [This is the length of the unprocessed precursor]

Molecular weight: 32992 Da [This is the MW of the unprocessed precursor]

CRC64: 982412E8EEE44083 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKFLLDVLLL LPLLIVCSLE SFVKLFIPKR RKSVTGEIVL ITGAGHGIGR LTAYEFAKLK 

        70         80         90        100        110        120 
SKLVLWDINK HGLEETAAKC KGLGAKVHTF VVDCSNREDI YSAAKKVKAE IGDVSILVNN 

       130        140        150        160        170        180 
AGVVYTSDLF ATQDPQIEKT FEVNVLAHFW TTKAFLPAMM KNNHGHIVTV ASAAGHVSVP 

       190        200        210        220        230        240 
FLLAYCSSKF AAVGFHKTLT DELAALQITG VKTTCLCPNF VNTGFIKNPS TSLGPTLEPE 

       250        260        270        280        290        300 
EVVNRLMHGI LTEQKMIFIP SSIAFLTTLE RILPERFLAV LKRKISVKFD AVIGYRMKAQ

Q5NVG2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools