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UniProtKB/Swiss-Prot entry Q5LI31

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DDL_BACFN
Primary accession number Q5LI31
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on June 21, 2005 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 32)
Name and origin of the protein
Protein name D-alanine--D-alanine ligase
Synonyms EC 6.3.2.4
D-alanylalanine synthetase
D-Ala-D-Ala ligase
Gene name
Name: ddl
OrderedLocusNames: BF0435
From
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [TaxID: 272559] [HAMAP proteome]
Taxonomy Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1107008; PubMed=15746427 [NCBI, ExPASy, EBI, Israel, Japan]
Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A., Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J.;
"Extensive DNA inversions in the B. fragilis genome control variable gene expression.";
Science 307:1463-1465(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR626927; CAH06197.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_210157.1; -.
3D structure databases
ModBase Q5LI31.
Enzyme and pathway databases
BioCyc BFRA272559:BF0435-MON; -.
Ontologies
GO
GO:0005618; Cellular component: cell wall (inferred from electronic annotation from InterPro).
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0008716; Molecular function: D-alanine-D-alanine ligase activity (inferred from electronic annotation from HAMAP).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0008360; Biological process: regulation of cell shape (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00047; -; 1.
PBIL [Tree]
InterPro IPR011761; ATP-grasp.
IPR013816; ATP_grasp_subdomain_2.
IPR000291; D-Ala_lig_Van_CS.
IPR005905; D_ala_D_ala.
IPR011095; Dala_Dala_lig_C.
IPR011127; Dala_Dala_lig_N.
IPR013817; Pre-ATP_grasp.
Graphical view of domain structure.
Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
G3DSA:3.40.50.20; Pre-ATP_grasp; 1.
Pfam PF07478; Dala_Dala_lig_C; 1.
PF01820; Dala_Dala_lig_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01205; D_ala_D_alaTIGR; 1.
PROSITE PS50975; ATP_GRASP; 1.
PS00843; DALA_DALA_LIGASE_1; 1.
PS00844; DALA_DALA_LIGASE_2; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q5LI31.
Genome annotation databases
GeneID 3285190; -.
GenomeReviews CR626927_GR; BF0435.
KEGG bfs:BF0435; -.
Phylogenomic databases
HOGENOM Q5LI31; -.
Genome annotation databases
CMR Q5LI31; BF0435.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   324  324     D-alanine--D-alanine ligase. PRO_1000030424
DOMAIN   121   321  201     ATP-grasp. 
NP_BIND   149   204  56     ATP (By similarity). 
METAL   275   275        Magnesium or manganese 1 (By similarity). 
METAL   288   288        Magnesium or manganese 1 (By similarity). 
METAL   288   288        Magnesium or manganese 2 (By similarity). 
METAL   290   290        Magnesium or manganese 2 (By similarity). 
Sequence information
Length: 324 AA [This is the length of the unprocessed precursor] Molecular weight: 36076 Da [This is the MW of the unprocessed precursor] CRC64: 514769F1E9649728 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKRNIAIVAG GDTSEIVVSL RSAQGIYSFI DKEKYNLYIV EMEGRRWEVQ LQDGSKTPVD 

        70         80         90        100        110        120 
RNDFSFMNGA EKVVFDFAYI TIHGTPGEDG RLQGYFDMIR IPYSCCGVLA AAITYDKFVC 

       130        140        150        160        170        180 
NQYLKAFGVR ISESLLLRQG QAVSDEDVVE KIGLPCFIKP NLGGSSFGVT KVKTREQIQP 

       190        200        210        220        230        240 
AIAKAFSEAE EVMIEAFMGG TELTCGCYKT KEKSVVFPLT EVVTHNEFFD YDAKYNGQVD 

       250        260        270        280        290        300 
EITPARISEE LTRRVQTLTS AIYDILGCSG IIRVDYIITE GEKINLLEVN TTPGMTATSF 

       310        320 
IPQQVRAAGL DIKDVMTDII ENKF
Q5LI31 in FASTA format

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