ID   CCPR_CRYNE              Reviewed;         377 AA.
AC   Q5KIK5; Q55TT2;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   04-NOV-2008, entry version 34.
DE   RecName: Full=Cytochrome c peroxidase, mitochondrial;
DE            Short=CCP;
DE            EC=1.11.1.5;
DE   Flags: Precursor;
GN   Name=CCP1; OrderedLocusNames=CND02630, CNBD3710;
OS   Cryptococcus neoformans (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Tremellomycetes; Tremellales; Tremellaceae; Filobasidiella;
OC   Filobasidiella/Cryptococcus neoformans species complex.
OX   NCBI_TaxID=5207;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A, and JEC21;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J.,
RA   D'Souza C.A., Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J.,
RA   Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I.,
RA   Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E.,
RA   Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L.,
RA   Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A.,
RA   Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R.,
RA   Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W.,
RA   Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen
RT   Cryptococcus neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Destroys radicals which are normally produced within the
CC       cells and which are toxic to biological systems (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2 ferrocytochrome c + H(2)O(2) = 2
CC       ferricytochrome c + 2 H(2)O.
CC   -!- COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group per
CC       subunit (By similarity).
CC   -!- SUBUNIT: Forms a one-to-one complex with cytochrome c (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
CC   -!- SIMILARITY: Belongs to the peroxidase family. Cytochrome c
CC       peroxidase subfamily.
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DR   EMBL; AE017344; AAW42936.1; -; Genomic_DNA.
DR   EMBL; AAEY01000020; EAL21317.1; -; Genomic_DNA.
DR   RefSeq; XP_570243.1; -.
DR   RefSeq; XP_775964.1; -.
DR   UniGene; Fne.3348; -.
DR   PeroxiBase; 2357; CnCcP01_JEC21.
DR   GeneID; 3257130; -.
DR   GeneID; 4935760; -.
DR   GenomeReviews; AE017344_GR; CND02630.
DR   KEGG; cnb:CNBD3710; -.
DR   KEGG; cne:CND02630; -.
DR   HOGENOM; Q5KIK5; -.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0004130; F:cytochrome-c peroxidase activity; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002207; Asc_perxdse.
DR   InterPro; IPR002016; Haem_peroxidase_pln/fun/bac.
DR   Pfam; PF00141; peroxidase; 1.
DR   PRINTS; PR00459; ASPEROXIDASE.
DR   PRINTS; PR00458; PEROXIDASE.
DR   PROSITE; PS00435; PEROXIDASE_1; 1.
DR   PROSITE; PS00436; PEROXIDASE_2; 1.
DR   PROSITE; PS50873; PEROXIDASE_4; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Heme; Iron; Metal-binding; Mitochondrion;
KW   Oxidoreductase; Peroxidase; Transit peptide.
FT   TRANSIT       1     17       Mitochondrion (Potential).
FT   CHAIN        18    377       Cytochrome c peroxidase, mitochondrial.
FT                                /FTId=PRO_0000045289.
FT   ACT_SITE    138    138       Proton acceptor (By similarity).
FT   ACT_SITE    277    277       Tryptophan radical intermediate (By
FT                                similarity).
FT   METAL       261    261       Iron (heme axial ligand).
FT   SITE        134    134       Transition state stabilizer (By
FT                                similarity).
SQ   SEQUENCE   377 AA;  42112 MW;  23FFFFF4EF188CB4 CRC64;
     MSFRAPNLIR SAAGRRASQT LNLRSQVIRR RFATEGGPEI TKPSSPRSSN TRYLLAGVGI
     AAVGAAYYFY GTGRTAHDSA NKADTVVRGA VATVEAKTGL RRGKDEYQKV YNRIAETLEK
     EGYDDGSLAP VLLRLAWHSS GTYNKEDGTG GSNFATMRFK PEAEHSANNG LHVAREHMEK
     IKQEFPWISY GDLWTLGGVC AVQESGGPTI PWRPGRIDGF EAQVTPDGRL PDASQAQDHL
     RFIFNRMGFN DQEIVALSGA HAMGRCHTNR SGFEGPWTFS PVTFSNQYFA LLRDEPWQWK
     KWTGPAQYED KNTKTLMMLP TDMALLKDKS FKKYVDIYAD NEEKFFSDFA KAFSKLIELG
     VPERQWAGEP WTLGTSD
//