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UniProtKB/Swiss-Prot entry Q5KFE0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATM_CRYNE
Primary accession number Q5KFE0
Secondary accession number Q55QS4
Integrated into Swiss-Prot on March 21, 2006
Sequence was last modified on February 15, 2005 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 32)
Name and origin of the protein
Protein name Serine/threonine-protein kinase TEL1
Synonyms EC 2.7.11.1
DNA-damage checkpoint kinase TEL1
Telomere length regulation protein 1
ATM homolog
Gene name
Name: TEL1
OrderedLocusNames: CNF02070, CNBF2640
From
Cryptococcus neoformans (Filobasidiella neoformans) [TaxID: 5207] 
Taxonomy Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Tremellaceae; Filobasidiella; Filobasidiella/Cryptococcus neoformans species complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=B-3501A, and JEC21;
DOI=10.1126/science.1103773; PubMed=15653466 [NCBI, ExPASy, EBI, Israel, Japan]
Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
"The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.";
Science 307:1321-1324(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE017346; AAW44228.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAEY01000031; EAL20188.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_571535.1; -.
XP_774835.1; -.
3D structure databases
ModBase Q5KFE0.
Ontologies
GO
GO:0000781; Cellular component: chromosome, telomeric region (inferred from electronic annotation from UniProtKB-KW).
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004674; Molecular function: protein serine/threonine kinase activity (inferred from electronic annotation from UniProtKB-KW).
GO:0016568; Biological process: chromatin modification (inferred from electronic annotation from UniProtKB-KW).
GO:0006281; Biological process: DNA repair (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR015519; Ataxia_Telang_Mut.
IPR003152; FATC.
IPR000357; HEAT.
IPR000403; PI3/4_kinase_cat.
IPR014009; PIK_FAT.
Graphical view of domain structure.
Gene3D G3DSA:1.10.1070.11; PI3/4_kinase_cat; 1.
PANTHER PTHR11139:SF3; Ataxia_Telang_Mut; 1.
Pfam PF02260; FATC; 1.
PF02985; HEAT; 2.
PF00454; PI3_PI4_kinase; 1.
Pfam graphical view of domain structure.
SMART SM00146; PI3Kc; 1.
SMART graphical view of domain structure.
PROSITE PS51189; FAT; 1.
PS51190; FATC; 1.
PS00915; PI3_4_KINASE_1; FALSE_NEG.
PS00916; PI3_4_KINASE_2; 1.
PS50290; PI3_4_KINASE_3; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q5KFE0.
Genome annotation databases
GeneID 3258065; -.
4936816; -.
GenomeReviews AE017346_GR; CNF02070.
KEGG cnb:CNBF2640; -.
cne:CNF02070; -.
Phylogenomic databases
HOGENOM Q5KFE0; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Chromatin regulator; Chromosomal protein; Complete proteome; DNA damage; DNA repair; Kinase; Nucleus; Serine/threonine-protein kinase; Telomere; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   2967  2967     Serine/threonine-protein kinase TEL1. PRO_0000227700
DOMAIN   1935   2523  589     FAT. 
DOMAIN   2651   2967  317     PI3K/PI4K. 
DOMAIN   2931   2967  37     FATC. 
VARIANT   142    142  1     A -> V (in strain: B-3501A). 
VARIANT   171    171  1     L -> H (in strain: B-3501A). 
VARIANT   336    336  1     G -> R (in strain: B-3501A). 
VARIANT   395    395  1     V -> I (in strain: B-3501A). 
VARIANT   444    444  1     S -> N (in strain: B-3501A). 
VARIANT   472    478  7     NDENNND -> DDDQSHN (in strain: B-3501A). 
VARIANT   501    501  1     P -> S (in strain: B-3501A). 
VARIANT   786    786  1     A -> V (in strain: B-3501A). 
VARIANT   795    795  1     E -> EE (in strain: B-3501A). 
VARIANT   854    854  1     P -> A (in strain: B-3501A). 
VARIANT   915    916  2     HE -> DD (in strain: B-3501A). 
VARIANT   972    972  1     G -> A (in strain: B-3501A). 
VARIANT   1128   1128  1     D -> Q (in strain: B-3501A). 
VARIANT   1275   1275  1     T -> A (in strain: B-3501A). 
VARIANT   1342   1342  1     A -> V (in strain: B-3501A). 
VARIANT   1380   1380  1     E -> K (in strain: B-3501A). 
VARIANT   2162   2162  1     V -> A (in strain: B-3501A). 
VARIANT   2165   2165  1     K -> R (in strain: B-3501A). 
VARIANT   2254   2254  1     Y -> D (in strain: B-3501A). 
Sequence information
Length: 2967 AA [This is the length of the unprocessed precursor] Molecular weight: 330906 Da [This is the MW of the unprocessed precursor] CRC64: FA723CFFAF25F542 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDSVSGLHAA LSLCASDSAK DRARAHALLP PIFANAQNLR VFQAAAATHG GAPWLALFHC 

        70         80         90        100        110        120 
LFRAVALEKR AVLRGSSNAQ AAARLAHAIR IVRLVAEQAV HLIARKPLIA LVAHMRHQLV 

       130        140        150        160        170        180 
LPPRIFAPAL LDYSKALSTL LAYPPHVESL DRHTWLALMS MCFAAILGDD LVSDDQMDDA 

       190        200        210        220        230        240 
DMLGVAAELE RLDAENVPPH RPPVTLNTSS LVQIIPALLC STVSPIVPPT MKSGDTLTAG 

       250        260        270        280        290        300 
QKVGLGIVLK IRRFFTMYPH VTIYHLHLLT ALNTVLSDME LNCRDLFLLG SVKIFPHLVT 

       310        320        330        340        350        360 
LWAAPERDRD RRIPEQIAIA IHRILPHLAH SAELQGAQDV TENVERLMEM LAKESTMSRG 

       370        380        390        400        410        420 
IEPLDLGTFP STATPSRQST PSKRRKLENP LASLVSAVGM GRPESRLIAL QTLVFVIDRH 

       430        440        450        460        470        480 
WSKLAKDIQS DIRRTLVSLL TDDSETLQSW AYIALSTIIL SSYTAGANEN NNDENNNDGQ 

       490        500        510        520        530        540 
SQDDWKQVWS FALRKCHLPG PSRSASHAAA VLLQFDKVDS PSTIRGIQTM LTTIAVQGPP 

       550        560        570        580        590        600 
TAHDSVCALY SIALEAARSD IQLYSLNLEE QVLSWLEKTF AREKFERDKM DQRLDQATPG 

       610        620        630        640        650        660 
DILRLFSAVS RIQYHVPLAE PVTKEFLPDS AVVSYALERA KTQPIRDFLL YHTCPTPPPP 

       670        680        690        700        710        720 
PPPLDDSHTT PLLAASENHS TFLGGRPRRL SELLLSILNA TTAQWETKPV ISSGERPRRC 

       730        740        750        760        770        780 
VDLVALGLAF QGLLQLDGYI PHAACINAAI RLLHLLKPSL TSSDLSIPSL DLVWRGLRCL 

       790        800        810        820        830        840 
ADVPLAKEEE EEEEEDWPIL VKPDVQSGIR QDLLPPTMYD TPPQEEEAES SDPPKRFTQY 

       850        860        870        880        890        900 
PPTFPSTLLP TPTPITPSSL STFQSQSNSA SLVHAIWRLP DVSAALQGLF SVCLQVITRS 

       910        920        930        940        950        960 
SSSTSSGQPT QLSHHEDDDG EDDDDDFAVA SGETTSAPLP EKAAELRAST SLLRSAVAFR 

       970        980        990       1000       1010       1020 
LQGVMLVSAG AGGGAQSKAY KDTQLVNSFL QADGLRAVEI GWAICEAMQK GWLRLGIDAV 

      1030       1040       1050       1060       1070       1080 
DLVVASLGNM LNSYGYARDE RLLQLCLEFL KCSAPVWMGN DHSNDDDLKD EAMRLVCYIA 

      1090       1100       1110       1120       1130       1140 
TKITAGSITS WRVRLAMLRF IEAFLHYDSA SKLWADCMVQ EEAEEEEDDV SMEDENHLFH 

      1150       1160       1170       1180       1190       1200 
YIAQSLSDPD MRVRARAATT AASALYRPSI HPSEHPIIYD QVSNSQAGDP TFAEHYLSYV 

      1210       1220       1230       1240       1250       1260 
LWKLNCCIAS AKQRQTVIFD LYEAAIGGTE YSDHLQAGLN AVARRLGLPS ITALYLPYAP 

      1270       1280       1290       1300       1310       1320 
TTTISHDTSR SSAITFVLNT THRLFGLSNR SAFFTACLEH AGAYMLYCGK IGLFTSACDA 

      1330       1340       1350       1360       1370       1380 
AGVLPEDLAL QLSVAAAAMA MALPLSNDKA TNVSMNKCKA EALALLSSFP GISGPDAAEE 

      1390       1400       1410       1420       1430       1440 
FLHSYANGVA AHLWELMDLE SSVDEIVAWF DKTEKESAAG IAFAQMMAHD NAKTGRVKAI 

      1450       1460       1470       1480       1490       1500 
NPAASFQSIH NVCRFLEKNY SSISLHAFTF AAILRLTSLI NNAFLVSEQR RYLRALAMLL 

      1510       1520       1530       1540       1550       1560 
SVHQGTLQRP LIWEAFLTET ITLLLQPDIC RTVLSMVMWA FDWLESLSST PSKLVNIFCQ 

      1570       1580       1590       1600       1610       1620 
LGEIRIELGG SGTPGSQPNQ MGDALEDWIV KMSPKWFKSQ ISQEAFERAV ALWPDSLRSR 

      1630       1640       1650       1660       1670       1680 
LSVHASPLSL RDLDDLSQND AVHNAGQLCK HFLHLADADH GQDVVSVFVD STFWSLKDKI 

      1690       1700       1710       1720       1730       1740 
SSVWDKEGIN AFQDLLYLCN GEVRAPSLNF YGQDTFSKAL NATTGEHKKT EAMNALYHAM 

      1750       1760       1770       1780       1790       1800 
CKTMVQLLHD RRPQIRSAAY RCLQRMKPIL TGKDLKELPA DVSDVVPILV PIPIGSVRQS 

      1810       1820       1830       1840       1850       1860 
QAMKLDGVIN NATWNKKAEH FATWSLELSR LLCKTASQHD KFFLSFEPLL STPLLPLHHF 

      1870       1880       1890       1900       1910       1920 
LGHFVHAALV CSRSMSSERS KAISEHFETV LQNPFASIEA VRSIVNIVLQ LRRYEHPFTS 

      1930       1940       1950       1960       1970       1980 
GMLGYNAWLS VNFVDLSKAA VKCGLYVSAL LFLELANDQG ESLDLAEPRV RQIMYDIYSN 

      1990       2000       2010       2020       2030       2040 
VEDPDGFYGI HNKDIRDSLR RRLEHEGLSW QALGWAGAVY NVDGNDSRSA IPVLHHLHDI 

      2050       2060       2070       2080       2090       2100 
GLSRLASVVA TETRTSGSVP LDDPFFADLS WRTGDWNLPI GRESSATSSG LLYSALSAVH 

      2110       2120       2130       2140       2150       2160 
RSKSYESASK IVDKAVRAEM TRLGGLQKEM LTSIQSTVTN LLCLRELNRW LDPQLQQGMQ 

      2170       2180       2190       2200       2210       2220 
EVIDKGTLRD LQDINDKFEF ASAERIIATR LSVFDSVKQR ESQDMIGDAL TPKMELVTKA 

      2230       2240       2250       2260       2270       2280 
ESTCHIKLSR LALKSNNLQA AINSLTALQK LQTYVGVIDE AQDVFCEVLW KQGEHTLAIQ 

      2290       2300       2310       2320       2330       2340 
LLEDLLLREK EKKSKGQRIP ALEGRLAHWA SEARLKAANE IFGMFSNVTK SIKRSTADVS 

      2350       2360       2370       2380       2390       2400 
EHAEIFYQFA CFADKQYVSQ SSSADVKQLK EYSKLRASQA LRLSARQSRA RESDQKDSAV 

      2410       2420       2430       2440       2450       2460 
REAERDEEKL KKFEMQQKQY LNAALQFYAE AVSMSDNFND CITRLVTLWL ENDENEESNV 

      2470       2480       2490       2500       2510       2520 
TFSRAAHKVP SYKFIFLGPQ LAARLHRPES PTIFNSTLNG LMFRMSQDHP YHTLYHVIPL 

      2530       2540       2550       2560       2570       2580 
LWEHKQPQST NSSMLGRKSA ADDIMRRLAS SASNRLAVGA AKSMKRFVAI AMEWTSFFEK 

      2590       2600       2610       2620       2630       2640 
DKRLEYKLPS DSPLRKAPRD IPVATSTPSI DVTCQYKDIA TFDHFSEWYT RAGGLSRPKV 

      2650       2660       2670       2680       2690       2700 
MTCFDSNGQK YTQLFKKDDG FRQDAVMEQI FVLVNDLLNR NRQTRSRKLR YRTYGVLALP 

      2710       2720       2730       2740       2750       2760 
EATGVIEFVV GTKPLIKYLP PAHEKYHPKD ITSHDFLKAM QEVQSVKNND EKIIQVWTKL 

      2770       2780       2790       2800       2810       2820 
KKRFRPVMRH LFTEKYRDPM AWFSMRLTYA RSLAVTSIVG WVLEIGDRHC SNILMDECTG 

      2830       2840       2850       2860       2870       2880 
ELVHIDFGIA FGAGRILPIP ELVPFRLTDD LVDALGVTGV NGTFRQCSQL VLQTLIDSSD 

      2890       2900       2910       2920       2930       2940 
VILTILEVFK QDPLHTWMVD DKMKKAQDGN HKMYPERGQE KADRIMRETR ENLSKELSVQ 

      2950       2960 
YRVNQLIQEA RDVNNLATIF RGWHSWL
Q5KFE0 in FASTA format

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