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UniProtKB/Swiss-Prot entry Q5K8D3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATG1_CRYNE
Primary accession number Q5K8D3
Secondary accession number Q55MD9
Integrated into Swiss-Prot on April 26, 2005
Sequence was last modified on July 19, 2005 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 32)
Name and origin of the protein
Protein name Serine/threonine-protein kinase ATG1
Synonyms EC 2.7.11.1
Autophagy-related protein 1
Gene name
Name: ATG1
OrderedLocusNames: CNL06100, CNBI0730
From
Cryptococcus neoformans (Filobasidiella neoformans) [TaxID: 5207] 
Taxonomy Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Tremellaceae; Filobasidiella; Filobasidiella/Cryptococcus neoformans species complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=B-3501A, and JEC21;
DOI=10.1126/science.1103773; PubMed=15653466 [NCBI, ExPASy, EBI, Israel, Japan]
Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
"The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.";
Science 307:1321-1324(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE017352; AAW46622.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAEY01000044; EAL18812.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_568139.1; -.
XP_773459.1; -.
UniGene Fne.283
3D structure databases
ModBase Q5K8D3.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0004674; Molecular function: protein serine/threonine kinase activity (inferred from electronic annotation from InterPro).
GO:0006914; Biological process: autophagy (inferred from electronic annotation from UniProtKB-KW).
GO:0006468; Biological process: protein amino acid phosphorylation (inferred from electronic annotation from InterPro).
GO:0015031; Biological process: protein transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.
Pfam PF00069; Pkinase; 1.
Pfam graphical view of domain structure.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q5K8D3.
Genome annotation databases
GeneID 3255019; -.
4938026; -.
GenomeReviews AE017352_GR; CNL06100.
KEGG cnb:CNBI0730; -.
cne:CNL06100; -.
Phylogenomic databases
HOGENOM Q5K8D3; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Autophagy; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Protein transport; Serine/threonine-protein kinase; Transferase; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   988  988     Serine/threonine-protein kinase ATG1. PRO_0000085644
DOMAIN   27   346  320     Protein kinase. 
NP_BIND   33    41  9     ATP (By similarity). 
ACT_SITE   183   183        Proton acceptor (By similarity). 
BINDING   56    56        ATP (By similarity). 
VARIANT   140   140  1     D -> N (in strain: B-3501A). 
VARIANT   517   517  1     A -> T (in strain: B-3501A). 
VARIANT   617   617  1     A -> T (in strain: B-3501A). 
VARIANT   625   625  1     P -> A (in strain: B-3501A). 
VARIANT   962   962  1     D -> E (in strain: B-3501A). 
Sequence information
Length: 988 AA [This is the length of the unprocessed precursor] Molecular weight: 107248 Da [This is the MW of the unprocessed precursor] CRC64: CDF0107160D35036 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPDSNAQGSR EKESGHHRSH KERIGNYVVG AEIGRGSFAT VYKGYRSKTR VPIAIKAVSR 

        70         80         90        100        110        120 
QKLTSKLLEN LESEINILKV INHRNIVALT DCFKNDTHIY LVMEYCSGSD LSVYIKQRGN 

       130        140        150        160        170        180 
IPTLDFVPKA GSSMALLPTD DEGKIYWPHP PTGGLDERVT RSFLGQLAQA IKFLRAQDLM 

       190        200        210        220        230        240 
HRDIKPQNLL LQPATETEVA EGHPYGIPVL KVADFGFARI LPAAAMAETL CGSPLYMAPE 

       250        260        270        280        290        300 
ILRYEKYDAK ADLWSVGAVL FEMSVGRPPF RANNHVELLR RIEKSNDNIV FPDEKERDSK 

       310        320        330        340        350        360 
SSDETSIPVP SDIKALIRAL LKRKPNDRMG FDDFFNCGVW DGHMAESTEE ESLSLDVSTD 

       370        380        390        400        410        420 
SSAGLGESDR IRQMVASTEQ SKDRLIPTRA PQPLAADAAL NPQPAVPISR DTSEGRSRLS 

       430        440        450        460        470        480 
TPPSRPTPTR RSTPKYYVGD ATPSEPTAII PPSPSSAPTP TSAPDPGLTT QQSPTSRANP 

       490        500        510        520        530        540 
RPIITAASSA QRRMSGKGDG REASSVEEAA PITPPFAGPS PTMARPSRGI NEGSPLAAAP 

       550        560        570        580        590        600 
PITMGPDGRL ERSSALEGST SGVGTDYVVV EKQTVEINAL ADELDQASKR PMIRRSSRGS 

       610        620        630        640        650        660 
VVSRPVSSFK PISPNIAKND PTLGPISYSP PFALSSTPPF AMQVPRHASG GNSFPRNPSI 

       670        680        690        700        710        720 
PSSLNAFPPT TISASPSYGQ DAAARFGVSP GSLQTGALAR ALTNTAIRLI GTSANTAATA 

       730        740        750        760        770        780 
IARATAKRRP NIVRVSDMDA AEDDLLCTVE DLARKAFVLF ELADERLLAQ TQLAQTARTS 

       790        800        810        820        830        840 
STPTGLTGTT PPFSMQAAAA AQAGSRRKSS SSSMNSEVWI LRQQEAAAND AVVLYMKSLA 

       850        860        870        880        890        900 
FIVKAMDKVK RYWKNRTDVY DGYVASQELN EMGQWLRARF NETFEKAEWA KTQAGDTLLF 

       910        920        930        940        950        960 
PDWLVHDKAR DTSRQAAVAE LQGDLTTAEQ GYETSLWLLQ ALLDESVYEN GSIPDEDKVA 

       970        980 
YDRLMVPIKT RLDALRKKLA ESSGMTAR
Q5K8D3 in FASTA format

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