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UniProtKB/Swiss-Prot entry Q5IZM4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP51_MYCVP
Primary accession number Q5IZM4
Secondary accession number A1TFI2
Integrated into Swiss-Prot on September 13, 2005
Sequence was last modified on February 15, 2005 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 30)
Name and origin of the protein
Protein name Cytochrome P450 51
Synonyms EC 1.14.13.70
CYPLI
P450-LIA1
Sterol 14-alpha demethylase
Lanosterol 14-alpha demethylase
P450-14DM
Gene name
Name: cyp51
OrderedLocusNames: Mvan_5161
From
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [TaxID: 350058] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Brezna B., Stingley R.L., Freeman J.P., Khan A.A., Cerniglia C.E.;
"The cytochromes p450 from PAH-degrading strain Mycobacterium vanbaalenii PYR-1.";
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P.;
"Complete sequence of Mycobacterium vanbaalenii PYR-1.";
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY575951; AAT40578.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CP000511; ABM15932.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_955938.1; -.
3D structure databases
SMR Q5IZM4; 7-449.
ModBase Q5IZM4.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002403; Cyt_P450_E_grp-IV.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00465; EP450IV.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS Q5IZM4.
Genome annotation databases
GeneID 4647445; -.
GenomeReviews CP000511_GR; Mvan_5161.
KEGG mva:Mvan_5161; -.
CMR Q5IZM4; Mvan_5161.
Other
ProtoNet Q5IZM4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Heme; Iron; Lipid synthesis; Metal-binding; Monooxygenase; NADP; Oxidoreductase; Steroid biosynthesis; Sterol biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   452  452     Cytochrome P450 51. PRO_0000052018
METAL   395   395        Iron (heme axial ligand). 
Sequence information
Length: 452 AA [This is the length of the unprocessed precursor] Molecular weight: 51681 Da [This is the MW of the unprocessed precursor] CRC64: 716ED23C210A2ADC [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTAVKEVPRV SGGEEEHGHL EEFRTDPIGL MKRVREECGD VGWFQLADKQ VILLSGAEAN 

        70         80         90        100        110        120 
EFFFRSSDSE LNQAEAYPFM TPIFGEGVVF DADPERRAEM LHNTALRGEH MKGHATTIEA 

       130        140        150        160        170        180 
EVRKMIEGWG ESGEIDLLEF FAELTIYTST ACLIGLKFRN QLDSRFANYY HLLERGTDPL 

       190        200        210        220        230        240 
CYVDPYLPIE SFRIRDEARA GLVELVQDVM HGRIANPPKD KSDRDMLDVL VSIKDEDGNP 

       250        260        270        280        290        300 
RFTANEITGM FISLMFAGHH TSSGTSSWTL IELLRHPEFY AKVQQELDDL YADGQEVSFH 

       310        320        330        340        350        360 
ALRQIPSLDN ALKETLRLHP PLIILMRVAQ DEFEVAGYPI HKGQMVAASP AISNRIPEDF 

       370        380        390        400        410        420 
PNPDDFDPDR YEKPRQEDLI NRWTWIPFGA GKHRCVGAAF AQMQIKAIFS VLLREYEFEM 

       430        440        450 
AQPPESYQND HSKMVVQLAR PAKVRYRRRV RD 

Q5IZM4 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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