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UniProtKB/Swiss-Prot entry Q5HL59

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ROCA_STAEQ
Primary accession number Q5HL59
Secondary accession numbers None
Integrated into Swiss-Prot on November 22, 2005
Sequence was last modified on February 15, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 26)
Name and origin of the protein
Protein name 1-pyrroline-5-carboxylate dehydrogenase
Synonyms P5C dehydrogenase
EC 1.5.1.12
Gene name
Name: rocA
OrderedLocusNames: SERP2128
From
Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [TaxID: 176279] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.187.7.2426-2438.2005; PubMed=15774886 [NCBI, ExPASy, EBI, Israel, Japan]
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.;
"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain.";
J. Bacteriol. 187:2426-2438(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000029; AAW53020.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_189684.1; -.
3D structure databases
ModBase Q5HL59.
Enzyme and pathway databases
BioCyc SEPI176279:SERP2128-MON; -.
Ontologies
GO
GO:0003842; Molecular function: 1-pyrroline-5-carboxylate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006537; Biological process: glutamate biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00733; -; 1.
PBIL [Tree]
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR005932; d-1-pyrroline-5-COlate_DHase-2.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01237; D1pyr5carbox2; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS Q5HL59.
Genome annotation databases
GeneID 3241657; -.
GenomeReviews CP000029_GR; SERP2128.
KEGG ser:SERP2128; -.
TIGR SERP2128; -.
Phylogenomic databases
HOGENOM Q5HL59; -.
Other
ProtoNet Q5HL59.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   514  514     1-pyrroline-5-carboxylate dehydrogenase. PRO_0000056521
ACT_SITE   286   286        By similarity. 
ACT_SITE   320   320        By similarity. 
Sequence information
Length: 514 AA [This is the length of the unprocessed precursor] Molecular weight: 56876 Da [This is the MW of the unprocessed precursor] CRC64: 99EE786D43629FF4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MVVPFKNEPG IDFSVQTNVE RFNEELRKVK AQLGQDIPLV INGEKLTKTD TFNSVNPANT 

        70         80         90        100        110        120 
SQLIAKVSKA TQDDIEKAFE SANHAYQSWK KWSHKDRAEL LLRVAAIIRR RKEEISAIMV 

       130        140        150        160        170        180 
YEAGKPWDEA VGDAAEGIDF IEYYARSMME LADGKPVLDR EGEHNRYFYK PIGTGVTIPP 

       190        200        210        220        230        240 
WNFPFAIMAG TTLAPVVAGN TVLLKPAEDT VLTAYKLMEI LEEAGLPQGV VNFVPGDPKE 

       250        260        270        280        290        300 
IGDYLVDHKD THFVTFTGSR ATGTRIYERS AVVQEGQQFL KRVIAEMGGK DAIVVDNNVD 

       310        320        330        340        350        360 
TDLAAEAIVT SAFGFSGQKC SACSRAIVHQ DVHDEILEKA IQLTQKLTLG NTEENTFMGP 

       370        380        390        400        410        420 
VINQKQFDKI KNYIEIGKKE GKLETGGGTD DSTGYFIEPT IFSGLQSADR IMQEEIFGPV 

       430        440        450        460        470        480 
VGFIKVKDFD EAIEVANDTD YGLTGAVITN HREHWIKAVN EFDVGNLYLN RGCTAAVVGY 

       490        500        510 
HPFGGFKMSG TDAKTGSPDY LLNFLEQKVV SEMF
Q5HL59 in FASTA format

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