[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Embryo; NIH - Xenopus Gene Collection (XGC) project; Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity).
CATALYTIC ACTIVITY: L-aspartate + H₂O + NAD(P)⁺ = oxaloacetate + NH₃ + NAD(P)H.
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1 .
MISCELLANEOUS: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia (By similarity).
SIMILARITY: Belongs to the L-aspartate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC089631; AAH89631.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001015700.1; -.

UniGene

Str.33092

3D structure databases

ModBase

Q5FW48.

Family and domain databases

InterPro

IPR005106; Asp/hSer_DHase_NAD-bd.
IPR002811; Asp_DHase.
IPR011182; Asp_DHase_NAD_syn.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF01958; DUF108; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF005227; Asp_dh_NAD_syn; 1.

ProDom

PD017325; Asp_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]

BLOCKS

Q5FW48.

Genome annotation databases

GeneID

548417; -.

KEGG

xtr:548417; -.

Phylogenomic databases

HOVERGEN

Q5FW48; -.

Other

ProtoNet

Q5FW48.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; NADP; Oxidoreductase; Pyridine nucleotide biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 284`	`284`	`Putative L-aspartate dehydrogenase.`	`PRO_0000144904`
`BINDING`	`127 127`		`NAD; via amide nitrogen (By similarity).`
`BINDING`	`194 194`		`NAD (By similarity).`

Sequence information

Length: 284 AA [This is the length of the unprocessed precursor]

Molecular weight: 31054 Da [This is the MW of the unprocessed precursor]

CRC64: 790C024CBE196BCC [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSEERRMRIG VVGYGHIGKY LVDKIVREGA NHSMELAFVW NRRREKLSGA VDPRLQLQDL 

        70         80         90        100        110        120 
SDCQKWAADL IVEVAHPCIT REYGEKFLSV AHFLVGSPTA LADTVTEAKL RERARLSGNT 

       130        140        150        160        170        180 
LYVPCGALWG AEDIFKMAER GTLKALRITM TKHPNSFKLE GDLVQKNQEA MSNRTVLYEG 

       190        200        210        220        230        240 
PVRGLCPLAP NNVNTMAAAC MAAHTLGFDG VVGVLVSDPS VPDWHFVDIE VTGGTIEKTG 

       250        260        270        280 
QVFSVKTSRR NPAAPCSVTG SATFASFWSS LLACKGHGGR VYIC

Q5FW48 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools