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UniProtKB/Swiss-Prot entry Q5F3T9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UGDH_CHICK
Primary accession number Q5F3T9
Secondary accession numbers None
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on March 15, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 29)
Name and origin of the protein
Protein name UDP-glucose 6-dehydrogenase
Synonyms UDP-Glc dehydrogenase
UDP-GlcDH
UDPGDH
EC 1.1.1.22
Gene name
Name: UGDH
ORFNames: RCJMB04_7d7
From
Gallus gallus (Chicken) [TaxID: 9031] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=CB;
TISSUE=Bursa of Fabricius;
DOI=10.1186/gb-2004-6-1-r6; PubMed=15642098 [NCBI, ExPASy, EBI, Israel, Japan]
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.;
"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.";
Genome Biol. 6:RESEARCH006.1-RESEARCH006.9(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ851561; CAH65195.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001012599.1; -.
UniGene Gga.8846
3D structure databases
ModBase Q5F3T9.
Ontologies
GO
GO:0001702; Biological process: gastrulation with mouth forming second (inferred from sequence or structural similarity from AgBase).
QuickGo view.
Family and domain databases
InterPro IPR016040; NAD(P)-bd.
IPR017476; Nucleotide_sugar_DH.
IPR014027; UDP-Glc/GDP-Man_DHase_C.
IPR014026; UDP-Glc/GDP-Man_DHase_dimer.
IPR014028; UDP-Glc/GDP-Man_DHase_dimer-bd.
IPR001732; UDP-Glc/GDP-Man_DHase_N.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:3.40.50.1870; UDP-Glc/GDP-Man_DH_C; 1.
PANTHER PTHR11374; UDPG_MGDP_DH_Creg; 1.
Pfam PF00984; UDPG_MGDP_dh; 1.
PF03720; UDPG_MGDP_dh_C; 1.
PF03721; UDPG_MGDP_dh_N; 1.
Pfam graphical view of domain structure.
BLOCKS Q5F3T9.
Genome annotation databases
Ensembl ENSGALG00000014320; Gallus gallus. [Contig view]
GeneID 422792; -.
KEGG gga:422792; -.
Phylogenomic databases
HOGENOM Q5F3T9; -.
HOVERGEN Q5F3T9; -.
Other
ProtoNet Q5F3T9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   494  494     UDP-glucose 6-dehydrogenase. PRO_0000317478
NP_BIND   6    23  18     NAD (By similarity). 
REGION   162   165  4     Substrate binding (By similarity). 
ACT_SITE   276   276        Nucleophile (By similarity). 
BINDING   36    36        NAD (By similarity). 
BINDING   41    41        NAD (By similarity). 
BINDING   93    93        NAD (By similarity). 
BINDING   131   131        NAD; via amide nitrogen (By similarity). 
BINDING   165   165        NAD (By similarity). 
BINDING   220   220        Substrate (By similarity). 
BINDING   273   273        Substrate; via amide nitrogen (By similarity). 
BINDING   279   279        NAD (By similarity). 
BINDING   339   339        Substrate (By similarity). 
BINDING   346   346        NAD (By similarity). 
Sequence information
Length: 494 AA [This is the length of the unprocessed precursor] Molecular weight: 55064 Da [This is the MW of the unprocessed precursor] CRC64: B5D9F2590D366122 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MFEIKKICCI GAGYVGGPTC SVIAQMCPKI QVTVVDVNEA RINAWNSDTL PIYEPGLKEV 

        70         80         90        100        110        120 
VESCRGRNLF FSTSIDDAIR EADLVFISVN TPTKTYGMGK GRAADLKYIE ACARRIVQNS 

       130        140        150        160        170        180 
NGYKIVTEKS TVPVRAAESI RRIFDANTKP NLDLQVLSNP EFLAEGTAIK DLKNPDRVLI 

       190        200        210        220        230        240 
GGDDSPEGQK AVRALCAVYE HWVPKEKILT TNTWSSELSK LAANAFLAQR ISSINSISAL 

       250        260        270        280        290        300 
CEATGADVEE VARAIGTDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW 

       310        320        330        340        350        360 
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS IYISKYLMDE 

       370        380        390        400        410        420 
GAKLHIYDPK VPKEQIILDL SHPGVSEDNQ VSRLVTISQD PYEACDGAHA LVICTEWDMF 

       430        440        450        460        470        480 
KELDYERIHK KMLKPAFIFD GRRVLDDLHN ELQVIGFQIE TIGKKVSAKR IPFASSCEIP 

       490 
KFSLQDPPVK KPRV
Q5F3T9 in FASTA format

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