ID   DHCR7_BOVIN             Reviewed;         475 AA.
AC   Q5E9J5; A6QR24;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   04-NOV-2008, entry version 30.
DE   RecName: Full=7-dehydrocholesterol reductase;
DE            Short=7-DHC reductase;
DE            EC=1.3.1.21;
DE   AltName: Full=Sterol Delta(7)-reductase;
GN   Name=DHCR7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Production of cholesterol by reduction of C7-C8 double
CC       bond of 7-dehydrocholesterol (7-DHC) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Cholesterol + NADP(+) = cholesta-5,7-dien-3-
CC       beta-ol + NADPH.
CC   -!- PATHWAY: Steroid biosynthesis; cholesterol biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the ERG4/ERG24 family.
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DR   EMBL; BT020925; AAX08942.1; -; mRNA.
DR   EMBL; BC150084; AAI50085.1; -; mRNA.
DR   RefSeq; NP_001014927.1; -.
DR   UniGene; Bt.5449; -.
DR   Ensembl; ENSBTAG00000016465; Bos taurus.
DR   GeneID; 514745; -.
DR   KEGG; bta:514745; -.
DR   HOVERGEN; Q5E9J5; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0047598; F:7-dehydrocholesterol reductase activity; IEA:EC.
DR   GO; GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001171; ERG4_ERG24.
DR   Pfam; PF01222; ERG4_ERG24; 1.
DR   PROSITE; PS01017; STEROL_REDUCT_1; 1.
DR   PROSITE; PS01018; STEROL_REDUCT_2; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol biosynthesis; Endoplasmic reticulum; Lipid synthesis;
KW   Membrane; NADP; Oxidoreductase; Steroid biosynthesis;
KW   Sterol biosynthesis; Transmembrane.
FT   CHAIN         1    475       7-dehydrocholesterol reductase.
FT                                /FTId=PRO_0000207501.
FT   TRANSMEM     40     60       Potential.
FT   TRANSMEM    151    173       Potential.
FT   TRANSMEM    178    200       Potential.
FT   TRANSMEM    266    286       Potential.
FT   TRANSMEM    306    326       Potential.
FT   TRANSMEM    331    351       Potential.
FT   TRANSMEM    420    440       Potential.
SQ   SEQUENCE   475 AA;  54271 MW;  4712E8DBA76D0A91 CRC64;
     MAAKSQPSAP KTKSTSGLTN GNAAAQGQWG RAWEVDWFSL ASVIFLLLFA PFIVYYFIMA
     CDQYGCSLTV PVADLATGRA RLADIWARTP PVTAKAAQIY TAWVTLQVLL YMLLPDFCHK
     FLPGYVGGVQ EGAVTPAGAV NKYEINGLQA WLLTHLLWFA NAHLLGWFSP TIIFDNWIPL
     LWCANILGYT VSTFAMVKGY LFPTDARECK FTGNFFYNYM MGVEFNPRIG KWFDFKLFFN
     GRPGIVAWTL INLSFAAKQQ ELYGHVTNSM VLVNILQAIY VLDFFWNETW YLKTIDICHD
     HFGWYLGWGD CVWLPYLYTL QGLYLVYHPV QLPTYYALGV LLLGLLGYYI FRMTNHQKDL
     FRRTDGRCLI WGRKPKAIEC SYTSADGQRH HSKLLVSGFW GVARHFNYTG DLMGSLAYCL
     ACGGGHLLPY FYIIFMAILL THRCLRDEHR CANKYGRDWE HYTAAVPYRL LPGIF
//