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UniProtKB/Swiss-Prot entry Q5E9J5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHCR7_BOVIN
Primary accession number Q5E9J5
Secondary accession number A6QR24
Integrated into Swiss-Prot on September 13, 2005
Sequence was last modified on March 15, 2005 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 28)
Name and origin of the protein
Protein name 7-dehydrocholesterol reductase
Synonyms 7-DHC reductase
EC 1.3.1.21
Sterol Delta(7)-reductase
Gene name
Name: DHCR7
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1186/1471-2164-6-166; PubMed=16305752 [NCBI, ExPASy, EBI, Israel, Japan]
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
"Characterization of 954 bovine full-CDS cDNA sequences.";
BMC Genomics 6:166-166(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford;
TISSUE=Fetal skin;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BT020925; AAX08942.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC150084; AAI50085.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001014927.1; -.
UniGene Bt.5449
3D structure databases
ModBase Q5E9J5.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR001171; ERG4_ERG24.
Graphical view of domain structure.
Pfam PF01222; ERG4_ERG24; 1.
Pfam graphical view of domain structure.
PROSITE PS01017; STEROL_REDUCT_1; 1.
PS01018; STEROL_REDUCT_2; 1.
BLOCKS Q5E9J5.
Genome annotation databases
Ensembl ENSBTAG00000016465; Bos taurus. [Contig view]
GeneID 514745; -.
KEGG bta:514745; -.
Phylogenomic databases
HOVERGEN Q5E9J5; -.
Other
ProtoNet Q5E9J5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cholesterol biosynthesis; Endoplasmic reticulum; Lipid synthesis; Membrane; NADP; Oxidoreductase; Steroid biosynthesis; Sterol biosynthesis; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   475  475     7-dehydrocholesterol reductase. PRO_0000207501
TRANSMEM   40    60  21     Potential. 
TRANSMEM   151   173  23     Potential. 
TRANSMEM   178   200  23     Potential. 
TRANSMEM   266   286  21     Potential. 
TRANSMEM   306   326  21     Potential. 
TRANSMEM   331   351  21     Potential. 
TRANSMEM   420   440  21     Potential. 
Sequence information
Length: 475 AA [This is the length of the unprocessed precursor] Molecular weight: 54271 Da [This is the MW of the unprocessed precursor] CRC64: 4712E8DBA76D0A91 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAKSQPSAP KTKSTSGLTN GNAAAQGQWG RAWEVDWFSL ASVIFLLLFA PFIVYYFIMA 

        70         80         90        100        110        120 
CDQYGCSLTV PVADLATGRA RLADIWARTP PVTAKAAQIY TAWVTLQVLL YMLLPDFCHK 

       130        140        150        160        170        180 
FLPGYVGGVQ EGAVTPAGAV NKYEINGLQA WLLTHLLWFA NAHLLGWFSP TIIFDNWIPL 

       190        200        210        220        230        240 
LWCANILGYT VSTFAMVKGY LFPTDARECK FTGNFFYNYM MGVEFNPRIG KWFDFKLFFN 

       250        260        270        280        290        300 
GRPGIVAWTL INLSFAAKQQ ELYGHVTNSM VLVNILQAIY VLDFFWNETW YLKTIDICHD 

       310        320        330        340        350        360 
HFGWYLGWGD CVWLPYLYTL QGLYLVYHPV QLPTYYALGV LLLGLLGYYI FRMTNHQKDL 

       370        380        390        400        410        420 
FRRTDGRCLI WGRKPKAIEC SYTSADGQRH HSKLLVSGFW GVARHFNYTG DLMGSLAYCL 

       430        440        450        460        470 
ACGGGHLLPY FYIIFMAILL THRCLRDEHR CANKYGRDWE HYTAAVPYRL LPGIF 

Q5E9J5 in FASTA format

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