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UniProtKB/Swiss-Prot entry Q5BLE8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name RETST_DANRE
Primary accession number Q5BLE8
Secondary accession number Q6DBT4
Integrated into Swiss-Prot on March 7, 2006
Sequence was last modified on April 12, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 32)
Name and origin of the protein
Protein name Putative all-trans-retinol 13,14-reductase [Precursor]
Synonyms EC 1.3.99.23
All-trans-13,14-dihydroretinol saturase
RetSat
Gene name
Name: retsat
ORFNames: zgc:113107
From
Danio rerio (Zebrafish) (Brachydanio rerio) [TaxID: 7955] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC078372; AAH78372.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC090469; AAH90469.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001015061.1; -.
UniGene Dr.80063
3D structure databases
ModBase Q5BLE8.
Organism-specific databases
ZFIN ZDB-GENE-050320-11; retsat.
Gene expression databases
ArrayExpress Q5BLE8; -.
Ontologies
GO
GO:0051786; Molecular function: all-trans-retinol 13,14-reductase activity (inferred from direct assay from ZFIN).
QuickGo view.
Family and domain databases
InterPro IPR002937; Amino_oxidase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
Graphical view of domain structure.
Pfam PF01593; Amino_oxidase; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
ProDom PD139017; Phytn_dehydro; 1.
[Domain structure / List of seq. sharing at least 1 domain]
BLOCKS Q5BLE8.
Genome annotation databases
Ensembl ENSDARG00000018600; Danio rerio. [Contig view]
GeneID 325922; -.
KEGG dre:325922; -.
Phylogenomic databases
HOGENOM Q5BLE8; -.
HOVERGEN Q5BLE8; -.
Other
ProtoNet Q5BLE8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
FAD; Flavoprotein; Membrane; NAD; NADP; Oxidoreductase; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    22  22     Potential. 
CHAIN   23   607  585     Putative all-trans-retinol 13,14-reductase. PRO_0000225669
NP_BIND   65    93  29     FAD or NAD or NADP (Potential). 
CONFLICT   572   572        L -> S (in Ref. 1; AAH78372). 
Sequence information
Length: 607 AA [This is the length of the unprocessed precursor] Molecular weight: 67937 Da [This is the MW of the unprocessed precursor] CRC64: 4B387672D3AA2E02 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MWFAVVAIFL ALVAFLYRYV VGSGPNPFAI DTREPLKPMV FDRKLKNKVL KQGFLASRVP 

        70         80         90        100        110        120 
EDLDAVVVGS GIGGLAIAVL LAKVGKKVLV LEQHDRAGGC CHTFKEQGFE FDVGIHYIGE 

       130        140        150        160        170        180 
LSNHKPLRCI IDQMTNGQLQ WDPLENPFDN VVIGPPENRR IYQIYSGRKR YMDELKKCFP 

       190        200        210        220        230        240 
GEEKAIDEYV RLCKEVGQGV WVMVLLKFLP TPIANFLVRT GLANRLTSFS RYASRSLTDV 

       250        260        270        280        290        300 
VNELTQNKDL RAVLSYIFGT YGKIPKEASF SMHSLIVNHY MNGAWYPKGG ATEIAYHMIP 

       310        320        330        340        350        360 
IIEKAGGAVL VRAPVNRILL NDAKEAIGVS VLKGQEEVHV RAPIVISDAG IFNTYEYLLP 

       370        380        390        400        410        420 
KDVQTMPAIQ KQLSMLQHGD SGLSIFIGLD GTKEELGLKA DNYFIYPENN IDELLEDYRS 

       430        440        450        460        470        480 
GNREESAKKN PLIFVASPSA KDSTWPERTP GKSTLTVVSF ANYEWFEEWK DDKVKNRSTD 

       490        500        510        520        530        540 
YKQLKELFIN YILEAVTEIY PKIKDRIEYV DAGTPITNQH YIAAPRGEIY GADHGIPRFS 

       550        560        570        580        590        600 
AELNATIRAQ TPIKNLYLTG QDLMLCGFAG ALTGALTCGS VILNRNLHLE AFSLAKRVQN 


GNNKKKT
Q5BLE8 in FASTA format

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