[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. DOI=10.1186/1471-2164-6-166; PubMed=16305752 [NCBI, ExPASy, EBI, Israel, Japan] Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.; "Characterization of 954 bovine full-CDS cDNA sequences."; BMC Genomics 6:166-166(2005).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Hereford; TISSUE=Fetal muscle; NIH - Mammalian Gene Collection (MGC) project; Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1 .
SUBUNIT: Homodecamer; composed of 5 homodimers (By similarity).
SUBCELLULAR LOCATION: Mitochondrion (By similarity).
SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BT021513; AAX46360.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC123510; AAI23511.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001014957.1; -.

UniGene

Bt.12489

3D structure databases

SMR

Q58DT4; 1-275.

ModBase

Q58DT4.

Family and domain databases

InterPro

IPR016040; NAD(P)-bd.
IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11645; P5CR; 1.

Pfam

PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000193; Pyrrol-5-carb_rd; 1.

TIGR00112; proC; 1.

PS00521; P5CR; 1.

Genome annotation databases

Ensembl

ENSBTAG00000000042; Bos taurus. [Contig view]

GeneID

539606; -.

KEGG

bta:539606; -.

Phylogenomic databases

HOVERGEN

Q58DT4; -.

Other

ProtoNet

Q58DT4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Mitochondrion; NADP; Oxidoreductase; Proline biosynthesis; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 26`	`26`	`Mitochondrion (Potential).`
`CHAIN`	`27 320`	`294`	`Pyrroline-5-carboxylate reductase 1, mitochondrial.`	`PRO_0000270817`

Sequence information

Length: 320 AA [This is the length of the unprocessed precursor]

Molecular weight: 33454 Da [This is the MW of the unprocessed precursor]

CRC64: 0265F89F283CA765 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSVGFIGAGQ LAFALAKGFT AAGVVAAHKI MASSPDMDLA TVSALRKMGV NLTHHNKETV 

        70         80         90        100        110        120 
QHSDVLFLAV KPHIIPFILD EIAANIEARH IVVSCAAGVT ISSIEKKLTA FQPAPKVIRC 

       130        140        150        160        170        180 
MTNTPVVVRE GATVYATGTH AQVEDGRLLE QLMSSVGFCT EVEEDLIDAV TGLSGSGPAY 

       190        200        210        220        230        240 
AFTALDALAD GGVKMGLPRR LAVRLGAQAL LGAAKMLLDS EQHPGQLKDN VCSPGGATIH 

       250        260        270        280        290        300 
ALHVLESGGF RSLLIKAVEA SCTRTRELQS MADQEKVSPA AIKKTILDKV KLDSPPGTSL 

       310        320 
APSGHSKLLP RSMAPAGKQD

Q58DT4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools