REVIEW.
DOI=10.1021/bi015932+; PubMed=11841199 [NCBI, ExPASy, EBI, Israel, Japan]
Lindahl P.A.;
"The Ni-containing carbon monoxide dehydrogenase family: light at the end of the tunnel?";
Biochemistry 41:2097-2105(2002).

Comments

CATALYTIC ACTIVITY: CO + H₂O + A = CO₂ + AH₂.
COFACTOR: Binds 3 4Fe-4S clusters per homodimer (By similarity).
COFACTOR: Binds 2 nickel-iron-sulfur clusters per homodimer (By similarity).
SUBUNIT: Homodimer (By similarity).
DOMAIN: Cluster B is an all-cysteinyl-liganded 4Fe4S cluster; cluster C is a mixed Ni-Fe-S cluster which appears to be the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe4S cluster that bridges the two subunits of the CODH dimer (By similarity).
SIMILARITY: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
CAUTION: This protein lacks the conserved Cys in position 45; it is replaced by a Tyr. It is therefore possible that the D-cluster is either altered or missing in this protein, which may not form homodimers.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L77117; AAB98724.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

H64390; H64390.

RefSeq

NP_247713.1; -.

3D structure databases

HSSP

Q9F8A8; 1JJY. [HSSP ENTRY / PDB]

ModBase

Q58138.

Enzyme and pathway databases

BioCyc

MJAN243232:MJ_0728-MON; -.

Family and domain databases

InterPro

IPR016101; CO_DHase_a-bundle.
IPR010047; CO_DHase_cat.
IPR004137; Prismane.
IPR016099; Prismane-like_a/b-sand.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.1270.30; CO_DH_a-bundle; 1.
G3DSA:3.40.50.2030; Prismane-like_a/b-sand; 1.

Pfam

PF03063; Prismane; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF005023; CODH; 1.

TIGRFAMs

TIGR01702; CO_DH_cata; 1.

BLOCKS

Q58138.

Genome annotation databases

1451605; -.

L77117_GR; MJ0728.

mja:MJ0728; -.

fig|243232.1.peg.750; -.

TIGR

MJ0728; -.

Phylogenomic databases

HOGENOM

Q58138; -.

Other

ProtoNet

Q58138.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Nickel; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 624`	`624`	`Carbon monoxide dehydrogenase.`	`PRO_0000157143`
`METAL`	`37 37`		`Iron-sulfur 1 (4Fe-4S); shared with dimeric partner (By similarity).`
`METAL`	`46 46`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`49 49`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`54 54`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`65 65`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`256 256`		`Nickel-iron-sulfur (By similarity).`
`METAL`	`292 292`		`Nickel-iron-sulfur (By similarity).`
`METAL`	`336 336`		`Nickel-iron-sulfur (By similarity).`
`METAL`	`444 444`		`Nickel-iron-sulfur (By similarity).`
`METAL`	`475 475`		`Nickel-iron-sulfur (By similarity).`
`METAL`	`516 516`		`Nickel-iron-sulfur (By similarity).`

Sequence information

Length: 624 AA [This is the length of the unprocessed precursor]

Molecular weight: 67408 Da [This is the MW of the unprocessed precursor]

CRC64: FFB6AA3376D1050E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKNCIAAIPE VKEMVEKAKL KGIETPHTRF PNQFPKCPYG LKGVYCILCA NGPCRITEKT 

        70         80         90        100        110        120 
PYGVCGATAD VIVARNLCRA VAAGTSCYVH CAENAARALL SAGKGEGSYE IRNEKKLKFL 

       130        140        150        160        170        180 
AKKLGFDANK DAKQLAVEVA EFILDDMYKP RWEKSELVPK LCPEKRLEVF EKLDILPGGA 

       190        200        210        220        230        240 
KGEIVDALTK TSTNLNSNPM DLLVHCLRLG LHAGFTGLLM TCWLNDILFG SPKITVVENG 

       250        260        270        280        290        300 
FSSVKPNNVN IMITGHQHAL IQPLCEAAME EDLIKMAKEA GADEIKIIGA TCNGQDMETR 

       310        320        330        340        350        360 
IAHLPESFVG YIANNFTTEP LVATGLIDAV VSEFNCTFHG LKFVAEKTKT KLICIDDMAY 

       370        380        390        400        410        420 
VEGAEYIPWE PENAKEKARE IIKKAIEAFK ERKGMQKDYY DEKVKSVVGV GEESLVEFLG 

       430        440        450        460        470        480 
GSVKPLIELI ASGKIKGVVG VVGCSNLASG GHDNIIVTLT KELIKRDILV LAGGCVNSPL 

       490        500        510        520        530        540 
KHAGLFDPAS AELAGENLKE VCKSLGIPPV LNFGACLSIA RIEQVAVAIA EELGVDIPDL 

       550        560        570        580        590        600 
PVAASAPQWL EEQALADATY AVDMGFTVHV SPVPFVTGSE LVTKVLTEAV EGLTGGKLIP 

       610        620 
EPNPYKAADL LEQTIMEKRK KLGI

Q58138 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools