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UniProtKB/Swiss-Prot entry Q58116


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH_METJA
Primary accession number Q58116
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 53)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Synonyms HMG-CoA reductase
EC 1.1.1.34
Gene name
Name: hmgA
OrderedLocusNames: MJ0705
From
Methanocaldococcus jannaschii (Methanococcus jannaschii) [TaxID: 2190] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanococci; Methanococcales; Methanocaldococcaceae; Methanocaldococcus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
PubMed=8688087 [NCBI, ExPASy, EBI, Israel, Japan]
Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii.";
Science 273:1058-1073(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L77117; AAB98699.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A64388; A64388.
RefSeq NP_247690.1; -.
3D structure databases
HSSP P04035; 1HWI. [HSSP ENTRY / PDB]
ModBase Q58116.
Enzyme and pathway databases
BioCyc MJAN243232:MJ_0705-MON; -.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; FALSE_NEG.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q58116.
Genome annotation databases
GeneID 1451573; -.
GenomeReviews L77117_GR; MJ0705.
KEGG mja:MJ0705; -.
NMPDR fig|243232.1.peg.727; -.
TIGR MJ0705; -.
Phylogenomic databases
HOGENOM Q58116; -.
Other
ProtoNet Q58116.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Isoprene biosynthesis; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   405  405     3-hydroxy-3-methylglutaryl-coenzyme A reductase. PRO_0000114461
ACT_SITE   100   100        Charge relay system (By similarity). 
ACT_SITE   310   310        Charge relay system (By similarity). 
ACT_SITE   400   400        Proton donor (By similarity). 
Sequence information
Length: 405 AA [This is the length of the unprocessed precursor] Molecular weight: 44128 Da [This is the MW of the unprocessed precursor] CRC64: F8F8E4729A77DFC9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MENYNDILEK MLNGEIKPYQ LDKMFGSKIA TEIRRKFIEK KVGIEFKHIC NYSIDEEMAM 

        70         80         90        100        110        120 
KKNIENMIGA IQIPLGFAGP LKINGEYAKG EFYIPLATTE GALVASVNRG CSIITKCGGA 

       130        140        150        160        170        180 
TVRVIDDKMT RAPCLKTKSV VDAIKVRDWI RENFERIKEV AESTTRHGKL IKIEPILIVG 

       190        200        210        220        230        240 
RNLYPRFVFK TGDAMGMNMV TIATEKACNF IEGELKKEGI FVKTVAVSGN ACVDKKPSGM 

       250        260        270        280        290        300 
NLINGRGKSI VAEVFLTEKE VNKYLKTTSQ AIAEVNRLKN YIGSAISNSM GFNAHYANII 

       310        320        330        340        350        360 
GAIFLATGQD EAHIVEGSLG ITMAEVEDDG LYFSVTLPDV PIGTVGGGTR VETQKECLEM 

       370        380        390        400 
LGCYGDNKAL KFAEIVGAAV LAGELSLLGA LAAGHLGKAH QELGR 

Q58116 in FASTA format

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