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[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
PubMed=8688087 [NCBI, ExPASy, EBI, Israel, Japan]
Bult C.J.,
White O.,
Olsen G.J.,
Zhou L.,
Fleischmann R.D.,
Sutton G.G.,
Blake J.A.,
FitzGerald L.M.,
Clayton R.A.,
Gocayne J.D.,
Kerlavage A.R.,
Dougherty B.A.,
Tomb J.-F.,
Adams M.D.,
Reich C.I.,
Overbeek R.,
Kirkness E.F.,
Weinstock K.G.,
Merrick J.M., ![]()
Glodek A.,
Scott J.L.,
Geoghagen N.S.M.,
Weidman J.F.,
Fuhrmann J.L.,
Nguyen D.,
Utterback T.R.,
Kelley J.M.,
Peterson J.D.,
Sadow P.W.,
Hanna M.C.,
Cotton M.D.,
Roberts K.M.,
Hurst M.A.,
Kaine B.P.,
Borodovsky M.,
Klenk H.-P.,
Fraser C.M.,
Smith H.O.,
Woese C.R.,
Venter J.C.;
"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii.";
Science 273:1058-1073(1996).
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- FUNCTION: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2) (By similarity).
- CATALYTIC ACTIVITY: CO + H2O + A = CO2 + AH2.
- COFACTOR: Binds 7 4Fe-4S clusters per heterotetramer (Potential).
- COFACTOR: Binds 2 nickel-iron-sulfur clusters per heterotetramer (Potential).
- SUBUNIT: Heterotetramer of two alpha and two epsilon chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential).
- DOMAIN: Cluster B is an all-cysteinyl-liganded 4Fe4S cluster; cluster C is a mixed Ni-Fe-S cluster which appears to be the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe4S cluster that bridges the two subunits of the CODH dimer. May contain two additional 4Fe-4S clusters, dubbed E and F, that might reroute electron transfer along different paths.
- SIMILARITY: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
- SIMILARITY: Contains 2 4Fe-4S ferredoxin-type domains.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 774 AA [This is the length of the unprocessed precursor] |
Molecular weight: 85900 Da [This is the MW of the unprocessed precursor] |
CRC64: F7CFD66F15CB1C7E [This is a checksum on the sequence] |
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10 20 30 40 50 60
MVMGNNVEMD IKKLLTPLVK MKNANISMSI KFGEEEEEEW EPMGPTPMPK IPTLRHWDFK
70 80 90 100 110 120
LLERYPPFYM PICDLCCLCT FGKCDLSRGK KGACGLNIKA QQARIVLIAC CIGAACHAGH
130 140 150 160 170 180
SRHLVHHLIE TLGRDYPIDL GNEIEVEAPI ARTVTGIKPK TLGDLEKILD YCEEQITHLL
190 200 210 220 230 240
SAAHTGQEGD YLDFESKALH AGMIDDLARE AGDLAQIVAY NMPKGDEDAP LIELGFGCID
250 260 270 280 290 300
KSKPVILCIG HNVVPGSYIL EYLEENSMED EVEVCGICCT AIDITRVSDK PKVVGPLSRQ
310 320 330 340 350 360
LMFVRSGVAD VVIVDEQCIR TDILEEVLKT GAVLIATNEK MCLGLEDVSH MDEDEIIGYL
370 380 390 400 410 420
LRNRAALLLD EKKVGKVAVE VAKIVAKERK DRKTLPDLNE VVELAKQCTE CGWCNRNCPN
430 440 450 460 470 480
AFKVKEAMAL AKQGNFKGFI DLYKRCYGCG RCEAICPRNL PIVSMTTKVG EAYYKDLKFK
490 500 510 520 530 540
MRAGRGPIKD VEIRSVGAPI VFGDIPGVVA LVGCSNHPNG EEEVAMIAKE FLERKYIVVA
550 560 570 580 590 600
TGCAAMAIGM WKDKDGKTLY EKYPGEFRAG GLVNCGSCLS NCHITGAAIK IANIFAKVPL
610 620 630 640 650 660
RGNYAEVADY ILNKVGAVGV AWGAMSQKAA AIATGVNRWG IPVILGPHGA KYRRLYLSNG
670 680 690 700 710 720
EKFKVKDKKT GEILEIEPAP EHLIVTAENV KECICMIPKL CMRPNDTPKG RANKIYHYVD
730 740 750 760 770
VYEKYFGRMP PDLEKFVRTE KDIPFMMKDK IMAYLEEKGW KPLEKYPQDP TILY
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Q57617 in FASTA format |
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