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UniProtKB/Swiss-Prot entry Q55NZ6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name JHD1_CRYNE
Primary accession number Q55NZ6
Secondary accession number Q5KEG2
Integrated into Swiss-Prot on March 7, 2006
Sequence was last modified on March 7, 2006 (Sequence version 2)
Annotations were last modified on    September 23, 2008 (Entry version 23)
Name and origin of the protein
Protein name JmjC domain-containing histone demethylation protein 1
Synonyms EC 1.14.11.27
[Histone-H3]-lysine-36 demethylase 1
Gene name
Name: JHD1
OrderedLocusNames: CNG00620, CNBG4160
From
Cryptococcus neoformans (Filobasidiella neoformans) [TaxID: 5207] 
Taxonomy Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Tremellaceae; Filobasidiella; Filobasidiella/Cryptococcus neoformans species complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=B-3501A, and JEC21;
DOI=10.1126/science.1103773; PubMed=15653466 [NCBI, ExPASy, EBI, Israel, Japan]
Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
"The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.";
Science 307:1321-1324(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE017347; AAW44468.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAEY01000039; EAL19469.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_571775.1; -.
XP_774116.1; -.
3D structure databases
ModBase Q55NZ6.
Family and domain databases
InterPro IPR013129; TF_JmjC.
IPR003347; TF_JmjC_AAH.
IPR001965; Znf_PHD.
Graphical view of domain structure.
Pfam PF02373; JmjC; 1.
Pfam graphical view of domain structure.
SMART SM00558; JmjC; 1.
SM00249; PHD; 1.
SMART graphical view of domain structure.
PROSITE PS51184; JMJC; 1.
PS01359; ZF_PHD_1; 1.
PS50016; ZF_PHD_2; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q55NZ6.
Genome annotation databases
GeneID 3258972; -.
4937452; -.
GenomeReviews AE017347_GR; CNG00620.
KEGG cnb:CNBG4160; -.
cne:CNG00620; -.
Phylogenomic databases
HOGENOM Q55NZ6; -.
Other
ProtoNet Q55NZ6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Chromatin regulator; Complete proteome; Dioxygenase; Iron; Metal-binding; Nucleus; Oxidoreductase; Transcription; Transcription regulation; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   879  879     JmjC domain-containing histone demethylation protein 1. PRO_0000226795
DOMAIN   416   598  183     JmjC. 
ZN_FING   23   116  94     PHD-type. 
METAL   475   475        Iron; catalytic (By similarity). 
METAL   477   477        Iron; catalytic (By similarity). 
METAL   566   566        Iron; catalytic (By similarity). 
BINDING   472   472        Substrate (By similarity). 
BINDING   492   492        Substrate (By similarity). 
VARIANT   401   401  1     N -> S (in strain: B-3501A). 
VARIANT   421   421  1     G -> S (in strain: B-3501A). 
VARIANT   620   620  1     E -> D (in strain: B-3501A). 
VARIANT   854   854  1     I -> V (in strain: B-3501A). 
Sequence information
Length: 879 AA [This is the length of the unprocessed precursor] Molecular weight: 98240 Da [This is the MW of the unprocessed precursor] CRC64: 2FF7F5CE7547B6EA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSEQVGQREA VDSPQATGVK TPPEPCPLCR ETGPPQPPSI TEEGKTNEDI DFIWVACNKC 

        70         80         90        100        110        120 
DEWYHSACLF LGDEKWRGTI PKEIISTVET NFGDEGAWTN WVEWIGKWYC APCLARSTSP 

       130        140        150        160        170        180 
SNPRPPRHPL VATMKRASIQ PKDIDQAGKP LKRSASTSAP LLKSNIKRPR TSTKGQETAS 

       190        200        210        220        230        240 
PEIDMKSERE QQAESTAGTP ASDAPQGRPK RKTAQIDYRN LNNSIATPTH QWLELIADPE 

       250        260        270        280        290        300 
KYGRTILDAN YPALPGKLLT RAWLESQPLP GQPSSISPDL LPTRFWGPDR EPLIVRPENG 

       310        320        330        340        350        360 
GFSSLGGHLP SKDLTVQDVA NLVGPDRMVD VIDVSSQHSS QWTLQKWAEY IQSSSGNTSV 

       370        380        390        400        410        420 
RNPKVYNVIS LEISGTELAK KVKPPKIVRE IDWVDNFWRF NAGAGGKDVK EKGRGNDSRE 

       430        440        450        460        470        480 
GSEIRKEGSH LTEGDNAGGE IEEDLEGLKE KTNTPYPKVQ LYCLMGMKGA WTDWHVDFAA 

       490        500        510        520        530        540 
SSVYYTIHSG AKVKLSCFVS FFSPGSYHSQ VFFFVKPTEQ NLKAYAEWSG SYEKQQDTWL 

       550        560        570        580        590        600 
GDMVDEVRKV ELHAGDTMII PTGYIHAVYT PMDSIVFGGN FLHSYNVDTQ LRLRQIEIDT 

       610        620        630        640        650        660 
KVPQRFRFPM FDRLCWYVAE KYCSDLRHLR AYRPRATTTP KPPHFRVLQC LSYLANFLVS 

       670        680        690        700        710        720 
QTGILEDPEA EDKARKLVHD RIPGDIVKDP EGLAKELKWR VERELGALGL LGEEASGVEA 

       730        740        750        760        770        780 
EEFKSNGTAN GSVKIKGKEV SRKRDRLSKV FDKKAISRTW DFHPPAWSEN RQSPQIETTT 

       790        800        810        820        830        840 
VQLPRPSTSS SDAISGSGPG ASPGASANGG ANENEQAELT TMLVKQTRKR MRELDDGTVI 

       850        860        870 
EESQETTFVE KKTIWGPKLD KEKISQPQGK VEEDMDIDH
Q55NZ6 in FASTA format

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