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UniProtKB/Swiss-Prot entry Q55FT1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DPYD_DICDI
Primary accession number Q55FT1
Secondary accession number Q5ZQQ8
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on May 24, 2005 (Sequence version 1)
Annotations were last modified on    September 23, 2008 (Entry version 33)
Name and origin of the protein
Protein name Dihydropyrimidine dehydrogenase [NADP+]
Synonyms DHPDHase
DPD
EC 1.3.1.2
Dihydrouracil dehydrogenase
Dihydrothymine dehydrogenase
Gene name
Name: pyd1
ORFNames: DDB_0231100
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Gojkovic Z., Sandrini M.P.B., Piskur J.;
"Dihydropyrimidine dehydrogenases and the evolution of the pyrimidine degradation pathway.";
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF545064; AAQ11981.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAFI02000003; EAL73436.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_647452.1; -.
3D structure databases
ModBase Q55FT1.
Organism-specific databases
dictyBase DDB0231100; pyd1.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from sequence or structural similarity from UniProtKB).
GO:0017113; Molecular function: dihydropyrimidine dehydrogenase (NADP+) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0006214; Biological process: thymidine catabolic process (inferred from sequence or structural similarity from UniProtKB).
GO:0006212; Biological process: uracil catabolic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR000759; Adrndx_reductase.
IPR013785; Aldolase_TIM.
IPR005720; DHO_DHase_1_core.
IPR001295; Dihydroorotate_DHase_core.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR012285; Fum_reductase_C.
IPR016040; NAD(P)-bd.
IPR000103; Pyridine_nuc-diS_OxRdtase_2.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01180; DHO_dh; 1.
PF00037; Fer4; 2.
PF07992; Pyr_redox_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PR00419; ADXRDTASE.
PR00368; FADPNR.
PR00469; PNDRDTASEII.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01037; pyrD_sub1_fam; 1.
PROSITE PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 3.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q55FT1.
Genome annotation databases
GeneID 3398478; -.
KEGG ddi:DDB_0231100; -.
Other
ProtoNet Q55FT1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; Cytoplasm; FAD; Flavoprotein; FMN; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1009  1009     Dihydropyrimidine dehydrogenase [NADP+]. PRO_0000327500
DOMAIN   69     99  31     4Fe-4S ferredoxin-type 1. 
DOMAIN   932    964  33     4Fe-4S ferredoxin-type 2. 
DOMAIN   965    995  31     4Fe-4S ferredoxin-type 3. 
NP_BIND   334    350  17     NADP (Potential). 
NP_BIND   468    479  12     FAD (Potential). 
REGION   659    676  18     Uracil binding (Potential). 
METAL   941    941        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   944    944        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   947    947        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   951    951        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   974    974        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   977    977        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   980    980        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   984    984        Iron-sulfur 2 (4Fe-4S) (Potential). 
CONFLICT   68     68        E -> G (in Ref. 1; AAQ11981). 
CONFLICT   234    234        R -> H (in Ref. 1; AAQ11981). 
CONFLICT   532    532        S -> C (in Ref. 1; AAQ11981). 
Sequence information
Length: 1009 AA [This is the length of the unprocessed precursor] Molecular weight: 110444 Da [This is the MW of the unprocessed precursor] CRC64: CBC49049106B86B7 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTGHTGDVSQ VHDIEILALN PTVNKHATFK PTIVSKKDKE NWARLDHCKK GCELKNDFED 

        70         80         90        100        110        120 
VKPTTLTERG ALFESARCLK CADAPCQKGC PTQLDIKSFI SSISTKNYYG AAKTIFSDNP 

       130        140        150        160        170        180 
LGLTCGMVCP VSSLCQYGCN LAATEEGPIN IGGLQQFATE VFKKMNIPQI RDPSLTPLSQ 

       190        200        210        220        230        240 
LPESYKAKIA LIGCGPTSIS CATFLGRLGY TDVTIFEKEQ YLGGLSSSEI PNYRLNYEVV 

       250        260        270        280        290        300 
EFEIKLMKDL GVKVEYGKRL GENGFTVESL QKQGYEAIYL GIGMPEPKID PVFNELTSDQ 

       310        320        330        340        350        360 
GFFSSKEFLP KVSKASKAGM CGCKSQLPQL NGRVIVLGAG DTAFDCATSA FRCGASRVTV 

       370        380        390        400        410        420 
CFRRGFSDMR AVPEEVDIAK DERCEFLPYV LPKQVIKRDG KVVAMEFYKT EKGDDGNYSV 

       430        440        450        460        470        480 
DEDQFFRVKC DYIISAFGSQ IGSVAESCSP LQFNKWGTAD IDPMTMTSKH AEWLFCGGDL 

       490        500        510        520        530        540 
VGNGTTVEAV NDGKTASWNI HKYLQSLHGI PIPDGPPQLP NFFTPIDLVD ISVEMCGMKF 

       550        560        570        580        590        600 
PNPFGLASAT PATSAAMIRR SFEQGWGFAV TKTFSLDKDL VTNVSPRIVR GTTSGHHFGP 

       610        620        630        640        650        660 
GQGAFLNIEL ISEKTCHYWC KAIGELKRDF PDRIVIASIM CGFNKEDWTQ LAKMAEASGA 

       670        680        690        700        710        720 
DGIELNLSCP HGMGEKGMGL ACGQDTELVF HICQWVRAAT RLPFFAKLTP NVTEIKEIAK 

       730        740        750        760        770        780 
AAHDGGADGV TAINTVSGLM GLKGDSNAWP AIGDEKRTTY GGVSGNATRP IALRAVSSIR 

       790        800        810        820        830        840 
KSLPDYPIMA TGGADSADAT IQFLHCGASV VQICSSVQNQ DFTVVQDYIT GLKTYLYMQS 

       850        860        870        880        890        900 
REDLLQWDGQ SPPNEIINKN PKLKGLPKFG KYLLERNRID TEEKQNIDLQ KVKNPLVPSP 

       910        920        930        940        950        960 
NPTHPVPSLK DQINRAIPRI GRHDDLKRDQ QVVALIDEDK CINCGKCYMT CNDSGYQAIK 

       970        980        990       1000 
FDGKTHIPLV TDLCTGCDLC LSVCPVPDCI TMVPRETIYV PDRGLTVQN 

Q55FT1 in FASTA format

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