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UniProtKB/Swiss-Prot entry Q55BI2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDHA_DICDI
Primary accession number Q55BI2
Secondary accession numbers None
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on May 24, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 21)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial [Precursor]
Synonym EC 1.1.1.41
Gene name
Name: idhA
ORFNames: DDB_0231288
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature00847; PubMed=12097910 [NCBI, ExPASy, EBI, Israel, Japan]
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.;
"Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
Nature 418:79-85(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAFI02000006; EAL71802.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_645630.1; -.
3D structure databases
ModBase Q55BI2.
Organism-specific databases
dictyBase DDB0231288; idhA.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from sequence or structural similarity from UniProtKB).
GO:0004449; Molecular function: isocitrate dehydrogenase (NAD+) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0006102; Biological process: isocitrate metabolic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR004434; IsoCit_DHase_NAD_mit.
IPR001804; IsoCit_IM_DHase.
IPR010916; TonB_box_CS.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00175; mito_nad_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q55BI2.
Genome annotation databases
GeneID 3396844; -.
KEGG ddi:DDB_0231288; -.
Other
ProtoNet Q55BI2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   354        Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial. PRO_0000328018
NP_BIND   276   282  7     NADP (By similarity). 
METAL   243   243        Magnesium or manganese (By similarity). 
BINDING   95    95        Substrate (By similarity). 
BINDING   97    97        Substrate (By similarity). 
BINDING   101   101        Substrate (By similarity). 
BINDING   111   111        Substrate (By similarity). 
BINDING   132   132        Substrate (By similarity). 
BINDING   289   289        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
SITE   139   139  1     Critical for catalysis (By similarity). 
SITE   186   186  1     Critical for catalysis (By similarity). 
Sequence information
Length: 354 AA [This is the length of the unprocessed precursor] Molecular weight: 38341 Da [This is the MW of the unprocessed precursor] CRC64: 07BC0DC939425EBE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MFSRKSLSIF STLRNYSSST SKIQKVTLIP GDGIGPEISE SVKRVFSAVK APIEWETVVV 

        70         80         90        100        110        120 
DANTGISKEV IESISKNKIG LKGPISTPIG TGHQSLNLGL RKTFNLYANI RPCLSIPGHK 

       130        140        150        160        170        180 
TRYNNVNTVV VRENTEGEYS GIENQPVKGV AQSIKIITKE ASTRIAHYAF QYALANGRKK 

       190        200        210        220        230        240 
VTCIHKANIM KQSDGLFVKS CREVSTRYPS IKYEELTIDN NCMQLVLDPN QMDVMVLPNL 

       250        260        270        280        290        300 
YGDIVSDLCA GLIGGLGLTP SGNIGENGSA IFEAVHGTAP DIAGKNKANP TALILSSIMM 

       310        320        330        340        350 
LRHLGHFHEA SIIENAVLNT LTEGKVKTGD LGGNSSCSEY TDELVKKITE SLNK 

Q55BI2 in FASTA format

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