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UniProtKB/Swiss-Prot entry Q557D2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G6PD_DICDI
Primary accession number Q557D2
Secondary accession number Q869V9
Integrated into Swiss-Prot on December 4, 2007
Sequence was last modified on May 2, 2006 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 21)
Name and origin of the protein
Protein name Glucose-6-phosphate 1-dehydrogenase
Synonyms G6PD
EC 1.1.1.49
Gene names
Name: g6pd-1
Synonyms: zwf
ORFNames: DDB_0217233
and
Name: g6pd-2
Synonyms: zwf
ORFNames: DDB_0231285
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature00847; PubMed=12097910 [NCBI, ExPASy, EBI, Israel, Japan]
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.;
"Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
Nature 418:79-85(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AC115684; AAO52363.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAFI02000009; EAL70783.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAFI02000011; EAL70510.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_644436.1; -.
XP_644814.1; -.
3D structure databases
ModBase Q557D2.
Organism-specific databases
dictyBase DDB0231285; g6pd-1.
DDB0238739; g6pd-2.
Family and domain databases
InterPro IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23429; G6PDH; 1.
Pfam PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000110; G6PD; 1.
PRINTS PR00079; G6PDHDRGNASE.
ProDom PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00871; zwf; 1.
PROSITE PS00069; G6P_DEHYDROGENASE; 1.
BLOCKS Q557D2.
Genome annotation databases
GeneID 3395716; -.
3395832; -.
KEGG ddi:DDB_0231285; -.
ddi:DDB_0238739; -.
Other
ProtoNet Q557D2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   497  497     Glucose-6-phosphate 1-dehydrogenase. PRO_0000312855
ACT_SITE   243   243        Proton acceptor (By similarity). 
BINDING   19    19        NADP (By similarity). 
BINDING   51    51        NADP (By similarity). 
BINDING   181   181        Substrate (By similarity). 
BINDING   185   185        Substrate (By similarity). 
Sequence information
Length: 497 AA [This is the length of the unprocessed precursor] Molecular weight: 56697 Da [This is the MW of the unprocessed precursor] CRC64: 5ECF966E8C5AA31A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTSTPDSRSV LTVIILGASG DLAKKKTYPA LFGLYLRDLL PSNTIIYGYA RSHIEIGDFK 

        70         80         90        100        110        120 
ARISKGLKGD EEKKKQFLNL LHYHSGKYDE KASYDEFEKL ILAEEKKQQG VDKFNRLFYM 

       130        140        150        160        170        180 
AIPPSIFIEV SIGIHGSLIS KNGWSRVIVE KPFGRDLASS RELVSELGKL FKEKDLFRID 

       190        200        210        220        230        240 
HYLGKEMVQN LMVLRFANAV FEPLWSKSHI SSITITFKED IGTEGRGGYF DQFGIIRDVM 

       250        260        270        280        290        300 
QNHLLQVLSL VAMEPPVSLN ADDITNEKVK LLRCIQPIKM SEVVLGQYTS DPEGKIPAYL 

       310        320        330        340        350        360 
DDEGVPKDST TPTYAAAVFH INNPRWRGMP FILKCGKALD ERKTEVRIQF KRPDNFLFSD 

       370        380        390        400        410        420 
DDISRNELVM RIQPGEAVYL KLLSKKPGLE NKIEQTELDL SYRHRFENLD LPDAYERLIL 

       430        440        450        460        470        480 
DSIKGDHNLF VRDDELDVAW QIFTPLLDQI EKEKIKPEPY SFGSRGPKSA DELSKKFGFI 

       490 
RSLGYNWPGN SPQGSKK 

Q557D2 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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