ID   CYSH_SYNE7              Reviewed;         232 AA.
AC   Q55309; Q31K83; Q935X7;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 2.
DT   04-NOV-2008, entry version 58.
DE   RecName: Full=Phosphoadenosine phosphosulfate reductase;
DE            EC=1.8.4.8;
DE   AltName: Full=PAPS reductase, thioredoxin dependent;
DE   AltName: Full=PAdoPS reductase;
DE   AltName: Full=3'-phosphoadenylylsulfate reductase;
DE   AltName: Full=PAPS sulfotransferase;
GN   Name=cysH; Synonyms=par; OrderedLocusNames=Synpcc7942_2506;
GN   ORFNames=sea0019;
OS   Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2).
OC   Bacteria; Cyanobacteria; Chroococcales; Synechococcus.
OX   NCBI_TaxID=1140;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=93099269; PubMed=1463852; DOI=10.1007/BF00028905;
RA   Niehaus A., Gisselmann G., Schwenn J.D.;
RT   "Primary structure of the Synechococcus PCC 7942 PAPS reductase
RT   gene.";
RL   Plant Mol. Biol. 20:1179-1183(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Holtman C.K., Socias T., Mohler B.J., Chen Y., Min H., Golden S.S.,
RA   Youderian P., Sandoval P., Gonzalez A., Salinas I.;
RT   "Synechococcus elongatus PCC7942 genome sequence, cosmid 7H1 and
RT   2E8.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 1 of Synechococcus elongatus PCC
RT   7942.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reduction of activated sulfate into sulfite.
CC   -!- CATALYTIC ACTIVITY: Adenosine 3',5'-bisphosphate + sulfite +
CC       thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.
CC   -!- PATHWAY: Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite
CC       from sulfate: step 3/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the PAPS reductase family. CysH subfamily.
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DR   EMBL; M84476; AAA27328.1; -; Genomic_DNA.
DR   EMBL; U30252; AAL03931.1; -; Genomic_DNA.
DR   EMBL; CP000100; ABB58536.1; -; Genomic_DNA.
DR   PIR; S28609; S28609.
DR   RefSeq; YP_401523.1; -.
DR   HSSP; P17854; 1SUR.
DR   GeneID; 3774526; -.
DR   GenomeReviews; CP000100_GR; Synpcc7942_2506.
DR   KEGG; syf:Synpcc7942_2506; -.
DR   HOGENOM; Q55309; -.
DR   BioCyc; SELO1140:SYNPCC7942_2506-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:HAMAP.
DR   GO; GO:0004604; F:phosphoadenylyl-sulfate reductase (thioredo...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0019379; P:sulfate assimilation, phosphoadenylyl sulfa...; IEA:HAMAP.
DR   HAMAP; MF_00063; -; 1.
DR   InterPro; IPR004511; CysH.
DR   InterPro; IPR002500; PAPS_reduct.
DR   InterPro; IPR011800; PAPS_reductase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   Gene3D; G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.
DR   Pfam; PF01507; PAPS_reduct; 1.
DR   TIGRFAMs; TIGR00434; cysH; 1.
DR   TIGRFAMs; TIGR02057; PAPS_reductase; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Oxidoreductase.
FT   CHAIN         1    232       Phosphoadenosine phosphosulfate
FT                                reductase.
FT                                /FTId=PRO_0000100649.
FT   CONFLICT    218    218       S -> T (in Ref. 1; AAA27328).
SQ   SEQUENCE   232 AA;  26622 MW;  549FFECCB3BF89A6 CRC64;
     MPALLPSLTE INAQLADQAA TQIIQWAATE FGSGLVLSTS FGIQSAVMLH LATQVQPDIP
     VIWIDTGYLP TETYRFAAEL TERLKLNLKV YQSEISPARM EALYGRLWES ESVEDFNRYD
     QMRKVEPMNR ALQELGATAW LSGVRRQQTA HRQSMEIVEL KRDRYAIRPI LGWHSRDVYQ
     YLTAHDLPYH PLFDQGYVTV GDWHSSRPLQ ADDSDERSTR FRGLKQECGL HL
//