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UniProtKB/Swiss-Prot entry Q54QI4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HGD_DICDI
Primary accession number Q54QI4
Secondary accession number Q9GU65
Integrated into Swiss-Prot on December 4, 2007
Sequence was last modified on May 24, 2005 (Sequence version 1)
Annotations were last modified on    September 23, 2008 (Entry version 23)
Name and origin of the protein
Protein name Homogentisate 1,2-dioxygenase
Synonyms EC 1.13.11.5
Homogentisic acid oxidase
Homogentisate oxygenase
Homogentisicase
Gene name
Name: hgd
Synonyms: hgo
ORFNames: DDB_0191461
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 2-432.
Schmidt S.R.;
"Identification of HGO homologs in different organisms.";
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAFI02000057; EAL65497.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF189237; AAG17115.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_638887.1; -.
3D structure databases
ModBase Q54QI4.
Organism-specific databases
dictyBase DDB0191461; hgd.
Family and domain databases
InterPro IPR005708; Homogentis_dOase.
Graphical view of domain structure.
PANTHER PTHR11056; Homogentis_dOase; 1.
Pfam PF04209; HgmA; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01015; hmgA; 1.
BLOCKS Q54QI4.
Genome annotation databases
GeneID 3390419; -.
KEGG ddi:DDB_0191461; -.
Other
ProtoNet Q54QI4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   432  432     Homogentisate 1,2-dioxygenase. PRO_0000312407
METAL   333   333        Iron (By similarity). 
METAL   339   339        Iron (By similarity). 
METAL   369   369        Iron (By similarity). 
CONFLICT   2     4        ALE -> TRP (in Ref. 2; AAG17115). 
Sequence information
Length: 432 AA [This is the length of the unprocessed precursor] Molecular weight: 48234 Da [This is the MW of the unprocessed precursor] CRC64: F704C3DCA58CAC53 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MALEQIDYEY QSGFGNSFES EAIKGTLPKG RNAPQNCPLD LYAEQLSGNA FTAPRHTQQR 

        70         80         90        100        110        120 
SWLYRIRPSV CHTPLKPIDS GLVCDLNNLH VDPNQLRWKP FPITEDKPHD FVEGLITIAG 

       130        140        150        160        170        180 
AGHASVRHGL AIHIYTATKS MENKSFYNSD GDFLIVPQQG TLDIQTEFGF MKVKSGEICV 

       190        200        210        220        230        240 
IQRGITFSVN VEGPTRGYIC EVFGSHFKLP DLGPIGANGL ANPRDFLSPV AAYEKKEGIE 

       250        260        270        280        290        300 
HTKINKFLGK LFSATQTYSP FNVVAWHGNY CPYKYDLSLF CVVNSVSFDH LDPSIFTVLT 

       310        320        330        340        350        360 
APTNEVGVAA ADFVIFPPRW LVQENTFRPP YFHRNCMSEF MGLIRGVYEA KKEGFLPGGG 

       370        380        390        400        410        420 
SLHSCMTPHG PDSDTFYAAI KAELKPTKIP DVALAFMFES SLILGISDYA KKNFIDDDYW 

       430 
KCWQGLKDNS KI 

Q54QI4 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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