ID   P5CR1_DICDI             Reviewed;         551 AA.
AC   Q54IL7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-NOV-2008, entry version 23.
DE   RecName: Full=Pyrroline-5-carboxylate reductase 1;
DE            Short=P5C reductase 1;
DE            Short=P5CR 1;
DE            EC=1.5.1.2;
GN   Name=pycr1; ORFNames=DDB_G0288671;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA   Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA   Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA   Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA   Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA   Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA   Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA   Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA   Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA   Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA   Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA   Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA   Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA   Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA   Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA   Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA   Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SUBUNIT: Homodecamer; composed of 5 homodimers (By similarity).
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
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DR   EMBL; AAFI02000119; EAL63112.1; -; Genomic_DNA.
DR   RefSeq; XP_636614.1; -.
DR   GeneID; 3388184; -.
DR   KEGG; ddi:DDB_0232206; -.
DR   dictyBase; DDB_G0288671; pycr1.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:InterPro.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; NADP; Oxidoreductase;
KW   Proline biosynthesis.
FT   CHAIN         1    551       Pyrroline-5-carboxylate reductase 1.
FT                                /FTId=PRO_0000328304.
FT   COMPBIAS    297    388       His-rich.
FT   COMPBIAS    319    326       Poly-Gln.
FT   COMPBIAS    448    453       Poly-Gln.
FT   COMPBIAS    456    474       Poly-Gln.
FT   COMPBIAS    487    496       Poly-Gln.
FT   COMPBIAS    504    532       Asn-rich.
SQ   SEQUENCE   551 AA;  63009 MW;  6D15ED4680D6244D CRC64;
     MKLYDNGVAV LGCGNLGNAI AKGLVASKQF KSNQIVLTKR NLSTIEPLKR EGYHVTTSNH
     DAVSRCKIVI VCVVPAQLDD LLDSIKQSVT ENHIIISVVS GASIEDIRSH LEKDVPIVRA
     MPNTAIQHCQ SMTCLAIRSS HQKSTNSPSD KAKDNALEVA KKIFNCLGMS IVLSEEQIVP
     ATALCACGIA FFCRAIRAAA QGGCEIGFHA EDAIRIAAQT AKGAATLLLE NNFHPEYEID
     KVTTPQGCTI AGLNQMEHAG FSSAMIKGIV TSSDKAASLY TQKQQNKKQQ QLKQQQHQQH
     QHQQHQQHQQ QVQQQEPHQY QQQQQQSHQQ SQYNQGHNYG HQNQHHHNHD DQHQNYYNQD
     QKRRNNRKHR SNENYDNHHH HNQQYQQHQQ PTQQESQEQT QQPEQTQSTN QSNQRRNSES
     RNGKSPQKQP QKQSQVQQPS STTENTDQQQ QQQPPQEQQQ QQEQPQQPQE QQQQPNVVDE
     AERPKEQQQQ PQQQQQTIDK KGYNNNRRGG RHYSYNNNYN SHHHRHNGIN KNSSSMYHDE
     KRHEVKTEQI N
//