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UniProtKB/Swiss-Prot entry Q54CX6


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 3HIDH_DICDI
Primary accession number Q54CX6
Secondary accession numbers None
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on May 24, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 29)
Name and origin of the protein
Protein name Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Precursor]
Synonyms HIBADH
EC 1.1.1.31
Gene name
Name: hibA
ORFNames: DDB_0216217
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAFI02000194; EAL61086.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_629544.1; -.
3D structure databases
ModBase Q54CX6.
Organism-specific databases
dictyBase DDB0216217; hibA.
Family and domain databases
InterPro IPR015815; 3hydroxyacid_DHase/Rdtase.
IPR006115; 6PGDH_NAD-bd.
IPR013328; DHase_multihelical.
IPR011548; IsoBut3OH_DH.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
PANTHER PTHR22981; 3hydroxy_acid_DH; 1.
Pfam PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01692; HIBADH; 1.
PROSITE PS00895; 3_HYDROXYISOBUT_DH; FALSE_NEG.
BLOCKS Q54CX6.
Genome annotation databases
GeneID 3386227; -.
KEGG ddi:DDB_0216217; -.
Other
ProtoNet Q54CX6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion (By similarity). 
CHAIN   ?   321        Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial. PRO_0000327881
NP_BIND   23    52  30     NAD (By similarity). 
NP_BIND   86    87  2     NAD (By similarity). 
ACT_SITE   192   192        By similarity. 
BINDING   117   117        NAD; via amide nitrogen (By similarity). 
BINDING   267   267        NAD (By similarity). 
Sequence information
Length: 321 AA [This is the length of the unprocessed precursor] Molecular weight: 33936 Da [This is the MW of the unprocessed precursor] CRC64: 10F0626EFAB0AB7A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MFSSKKSLLL FKNVRYMSTS SSKTVGFIGL GNMGGHQAIN LIKKGHNLIV FDMSKDNMNR 

        70         80         90        100        110        120 
LKEKGAKIAN SPAEVAKEAD VIVTMLPASA HVKNVYCGEN GIFQTVRPGT LLLDSSTIDP 

       130        140        150        160        170        180 
ATAREVASIA KKHQSTMLDC PVSGGTGGAE AGTLTFMVGG SEQDFNTAKT YLECMGKNIV 

       190        200        210        220        230        240 
HCGDVGTGQV AKVCNNLVLG ISMIAVSEAM NLGVKQGMDP KKLAGIFNTS SARCWTSELY 

       250        260        270        280        290        300 
NPCPGVIETS PASRGYTGGF GSALMTKDLG LAVDSAKSIG EPLLLGNSAH QLYTLLVAKG 

       310        320 
DGQKDFSVVY DFLNKNFKNS N 

Q54CX6 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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NPSA logo NPSA Sequence analysis tools

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