ID   LOX4_ORYSJ              Reviewed;         877 AA.
AC   Q53RB0;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   04-NOV-2008, entry version 30.
DE   RecName: Full=Probable lipoxygenase 4;
DE            EC=1.13.11.12;
GN   OrderedLocusNames=Os03g0700700, LOC_Os03g49380;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade;
OC   Ehrhartoideae; Oryzeae; Oryza.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R.,
RA   Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L.,
RA   Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S., Johri S.,
RA   Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S.,
RA   Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J.,
RA   de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y.,
RA   Kim H.-I., Rambo T., Currie J., Collura K., Kernodle-Thompson S.,
RA   Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L.,
RA   Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C.,
RA   Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L.,
RA   Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H.,
RA   Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome
RT   3 and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   MEDLINE=22752273; PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Plant lipoxygenase may be involved in a number of
CC       diverse aspects of plant physiology including growth and
CC       development, pest resistance, and senescence or responses to
CC       wounding. Catalyzes the hydroperoxidation of lipids, containing a
CC       cis,cis-1,4-pentadiene structure (By similarity).
CC   -!- CATALYTIC ACTIVITY: Linoleate + O(2) = (9Z,11E)-(13S)-13-
CC       hydroperoxyoctadeca-9,11-dienoate.
CC   -!- COFACTOR: Binds 1 iron ion per subunit. Iron is tightly bound (By
CC       similarity).
CC   -!- PATHWAY: Lipid metabolism; oxylipin biosynthesis.
CC   -!- SIMILARITY: Belongs to the lipoxygenase family.
CC   -!- SIMILARITY: Contains 1 lipoxygenase domain.
CC   -!- SIMILARITY: Contains 1 PLAT domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AK072689; Type=Frameshift; Positions=686;
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DR   EMBL; AC093017; AAX95641.1; -; Genomic_DNA.
DR   EMBL; AK072689; -; NOT_ANNOTATED_CDS; mRNA.
DR   Gramene; Q53RB0; -.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0031408; P:oxylipin biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000907; LipOase.
DR   InterPro; IPR013819; LipOase_C.
DR   InterPro; IPR001024; LipOase_LH2.
DR   InterPro; IPR001246; LipOase_pln.
DR   Gene3D; G3DSA:2.60.60.20; Lipase_LipOase; 1.
DR   PANTHER; PTHR11771; LipOase; 1.
DR   Pfam; PF00305; Lipoxygenase; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   PRINTS; PR00087; LIPOXYGENASE.
DR   PRINTS; PR00468; PLTLPOXGNASE.
DR   SMART; SM00308; LH2; 1.
DR   PROSITE; PS00711; LIPOXYGENASE_1; 1.
DR   PROSITE; PS00081; LIPOXYGENASE_2; 1.
DR   PROSITE; PS51393; LIPOXYGENASE_3; 1.
DR   PROSITE; PS50095; PLAT; 1.
PE   2: Evidence at transcript level;
KW   Dioxygenase; Fatty acid biosynthesis; Iron; Lipid synthesis;
KW   Metal-binding; Oxidoreductase; Oxylipin biosynthesis.
FT   CHAIN         1    877       Probable lipoxygenase 4.
FT                                /FTId=PRO_0000220710.
FT   DOMAIN       38    165       PLAT.
FT   DOMAIN      168    877       Lipoxygenase.
FT   METAL       528    528       Iron; catalytic (By similarity).
FT   METAL       533    533       Iron; catalytic (By similarity).
FT   METAL       719    719       Iron; catalytic (By similarity).
FT   METAL       723    723       Iron; catalytic (By similarity).
FT   METAL       877    877       Iron; via carboxylate; catalytic (By
FT                                similarity).
SQ   SEQUENCE   877 AA;  98698 MW;  9B4EBB61CDCD9B7C CRC64;
     MQVQGFFDRL TGRNKEAWKE GRIRGTAVLV KKDVLGLGDF HASLLDGVHN ILGHKEGVAF
     RLVSATARDP SNGGRGKLGK PAHLEELVVT MKSTAAGESV FRVAFEWDES QGIPGAVVVT
     NSNRSEFFLK TLTLDGVPGK GTVVFVANSW IYPADNYQYE RVFFANDTYL PSKMPAPLIP
     YRQEELNILR GDGKIGPYKE HDRIYRYDYY NDLGQPDKGS KLVRPVLGGS QELPYPRRGR
     TGRAPTKTDP NTESRLPLLD LNIYVPRDER FGHLKMSDFL GYSLKAIVEG VLPIIRTYVD
     TTPKEFDSFQ DIMELYEGGL KVANASALAE IKKRVPFELI KSLLPVAGDQ VLKLPLPHVI
     KEDKFAWRTD EEFAREMLAG VNPVMIKRLT NFPAKSTLDP NVYGDHTSKI TEAHIKHNME
     GLTVQNALKG NRLFILDHHD HFMPFLDKIN KLDGNFIYAS RTILLLKDDG TLKPLAIELS
     LPHPDGQQHG AVSKVYTPAN TGVESQIWQL AKAYASVNDS AWHQLISHWL NTHAVIEPFV
     IATNRQLSVV HPVHKLLSPH YRDTMNINAL ARQTLINADG IFEKTVFPGK YALEMSSVVY
     KNWKFTEQAL PVDLVKRGVA VPDPTSPYNV RLLIKDYPYA VDGLVIWWAI ERWVGEYLAI
     YYPNDGVLRG DEELQAWWKE VREVGHGDLK DQDWWPKMDT VQELTRACTI IIWIASALHA
     AVNFGQYPYA GFLPNRPTVS RRPMPEPGTE EYAKLERGGD EADLVFIHTI TSQFQTILGI
     SLIEILSKHS SDEVYLGQRD TPEWTSDAKA LDAFKRFGSR LVDIENRIKD MNGNSALKNR
     NGPVKMPYML LYPNTSDVTK EKGQGLTAMG IPNSISI
//