ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q53H96


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name P5CR3_HUMAN
Primary accession number Q53H96
Secondary accession numbers Q8N3N9 Q96HX4 Q9H896
Integrated into Swiss-Prot on March 18, 2008
Sequence was last modified on March 18, 2008 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 25)
Name and origin of the protein
Protein name Pyrroline-5-carboxylate reductase 3
Synonyms P5C reductase 3
P5CR 3
EC 1.5.1.2
Pyrroline-5-carboxylate reductase-like protein
Gene name
Name: PYCRL
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-150.
TISSUE=Thyroid;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-264.
TISSUE=Brain;
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-274.
TISSUE=Amygdala;
The German cDNA consortium;
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK023914; BAB14721.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC007993; AAH07993.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK222685; BAD96405.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL833857; CAD38716.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_075566.1; -.
UniGene Hs.165186
3D structure databases
ModBase Q53H96.
Organism-specific databases
HGNC HGNC:25846; PYCRL.
GenAtlas PYCRL.
GeneCards Q53H96.
Gene expression databases
ArrayExpress Q53H96; -.
CleanEx HS_PYCRL; -.
Family and domain databases
InterPro IPR016040; NAD(P)-bd.
IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11645; P5CR; 1.
Pfam PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000193; Pyrrol-5-carb_rd; 1.
TIGRFAMs TIGR00112; proC; 1.
PROSITE PS00521; P5CR; 1.
BLOCKS Q53H96.
Proteomic databases
PeptideAtlas Q53H96; -.
Genome annotation databases
Ensembl ENSG00000104524; Homo sapiens. [Contig view]
GeneID 65263; -.
KEGG hsa:65263; -.
Phylogenomic databases
HOGENOM Q53H96; -.
HOVERGEN Q53H96; -.
Other
ProtoNet Q53H96.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; NADP; Oxidoreductase; Polymorphism; Proline biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   274  274     Pyrroline-5-carboxylate reductase 3. PRO_0000324561
VARIANT   57    57  1     R -> Q (in dbSNP:rs11549789 [NCBI]). VAR_039828 
VARIANT   105   105  1     V -> M (in dbSNP:rs2242089 [NCBI]). VAR_039829 
VARIANT   150   150  1     N -> K (in dbSNP:rs2242090 [NCBI]). VAR_039830 
Sequence information
Length: 274 AA [This is the length of the unprocessed precursor] Molecular weight: 28649 Da [This is the MW of the unprocessed precursor] CRC64: 846FD9B60183B048 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAAEPSPRR VGFVGAGRMA GAIAQGLIRA GKVEAQHILA SAPTDRNLCH FQALGCRTTH 

        70         80         90        100        110        120 
SNQEVLQSCL LVIFATKPHV LPAVLAEVAP VVTTEHILVS VAAGVSLSTL EELLPPNTRV 

       130        140        150        160        170        180 
LRVLPNLPCV VQEGAIVMAR GRHVGSSETN LLQHLLEACG RCEEVPEAYV DIHTGLSGSG 

       190        200        210        220        230        240 
VAFVCAFSEA LAEGAVKMGM PSSLAHRIAA QTLLGTAKML LHEGQHPAQL RSDVCTPGGT 

       250        260        270 
TIYGLHALEQ GGLRAATMSA VEAATCRAKE LSRK 

Q53H96 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by kr flag YPRC Korea Mirror sites: Australia  Brazil  Canada  China  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!