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UniProtKB/Swiss-Prot entry Q53586


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HPPD_STRAW
Primary accession number Q53586
Secondary accession number Q93HN6
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on May 9, 2003 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 65)
Name and origin of the protein
Protein name 4-hydroxyphenylpyruvate dioxygenase
Synonyms HPPDase
4HPPD
HPD
EC 1.13.11.27
Gene name
Name: hpd
OrderedLocusNames: SAV_5149
From
Streptomyces avermitilis [TaxID: 33903] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Streptomycineae; Streptomycetaceae; Streptomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 31272 / MA-4848;
PubMed=8071207 [NCBI, ExPASy, EBI, Israel, Japan]
Denoya C.D., Skinner D.D., Morgenstern M.R.;
"A Streptomyces avermitilis gene encoding a 4-hydroxyphenylpyruvic acid dioxygenase-like protein that directs the production of homogentisic acid and an ochronotic pigment in Escherichia coli.";
J. Bacteriol. 176:5312-5319(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165;
DOI=10.1073/pnas.211433198; PubMed=11572948 [NCBI, ExPASy, EBI, Israel, Japan]
Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.;
"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.";
Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165;
DOI=10.1038/nbt820; PubMed=12692562 [NCBI, ExPASy, EBI, Israel, Japan]
Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.;
"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.";
Nat. Biotechnol. 21:526-531(2003).
[4]
X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), METAL-BINDING SITES, AND SUBUNIT.
DOI=10.1021/bi049317s; PubMed=15157070 [NCBI, ExPASy, EBI, Israel, Japan]
Brownlee J.M., Johnson-Winters K., Harrison D.H.T., Moran G.R.;
"Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC.";
Biochemistry 43:6370-6377(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U11864; AAA50231.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB070935; BAB69150.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BA000030; BAC72861.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_826326.1; -.
3D structure databases
PDB
1T47; X-ray; 2.50 A; A/B=1-381.[ExPASy / RCSB / EBI]
PDBsum 1T47; -.
ModBase Q53586.
Enzyme and pathway databases
BioCyc SAVE227882:SAV5149-MON; -.
Family and domain databases
InterPro IPR005956; 4OHPhenylPyrv_dOase.
IPR004360; Glyas_bleo-R_dOase.
Graphical view of domain structure.
PANTHER PTHR11959; HPP_dOase; 1.
Pfam PF00903; Glyoxalase; 2.
Pfam graphical view of domain structure.
PIRSF PIRSF009283; HPP_dOase; 1.
TIGRFAMs TIGR01263; 4HPPD; 1.
BLOCKS Q53586.
Genome annotation databases
GeneID 1211215; -.
GenomeReviews BA000030_GR; SAV_5149.
KEGG sma:SAV5149; -.
NMPDR fig|227882.1.peg.5152; -.
Phylogenomic databases
HOGENOM Q53586; -.
Genome annotation databases
CMR Q53586; SAV_5149.
Other
ProtoNet Q53586.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   381  381     4-hydroxyphenylpyruvate dioxygenase. PRO_0000088409
METAL   187   187        Iron. 
METAL   270   270        Iron. 
METAL   349   349        Iron. 
CONFLICT   40    40        Missing (in Ref. 1; AAA50231). 
STRAND   22    29  8      
HELIX   33    42  10      
STRAND   47    53  7      
HELIX   54    56  3      
STRAND   60    68  9      
STRAND   71    80  10      
HELIX   84    96  13      
STRAND   98   106  9      
HELIX   110   119  10      
STRAND   124   133  10      
STRAND   136   144  9      
STRAND   150   159  10      
STRAND   161   164  4      
STRAND   184   191  8      
HELIX   197   208  12      
HELIX   219   222  4      
TURN   223   226  4      
STRAND   227   234  8      
STRAND   240   247  8      
STRAND   250   252  3      
HELIX   255   263  9      
STRAND   267   274  8      
HELIX   278   287  10      
HELIX   297   299  3      
HELIX   303   307  5      
HELIX   314   320  7      
STRAND   323   326  4      
STRAND   331   337  7      
STRAND   340   344  5      
STRAND   347   355  9      
HELIX   363   376  14      
Sequence information
Length: 381 AA [This is the length of the unprocessed precursor] Molecular weight: 41863 Da [This is the MW of the unprocessed precursor] CRC64: 4A3B3E7B646165D7 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTQTTHHTPD TARQADPFPV KGMDAVVFAV GNAKQAAHYY STAFGMQLVA YSGPENGSRE 

        70         80         90        100        110        120 
TASYVLTNGS ARFVLTSVIK PATPWGHFLA DHVAEHGDGV VDLAIEVPDA RAAHAYAIEH 

       130        140        150        160        170        180 
GARSVAEPYE LKDEHGTVVL AAIATYGKTR HTLVDRTGYD GPYLPGYVAA APIVEPPAHR 

       190        200        210        220        230        240 
TFQAIDHCVG NVELGRMNEW VGFYNKVMGF TNMKEFVGDD IATEYSALMS KVVADGTLKV 

       250        260        270        280        290        300 
KFPINEPALA KKKSQIDEYL EFYGGAGVQH IALNTGDIVE TVRTMRAAGV QFLDTPDSYY 

       310        320        330        340        350        360 
DTLGEWVGDT RVPVDTLREL KILADRDEDG YLLQIFTKPV QDRPTVFFEI IERHGSMGFG 

       370        380 
KGNFKALFEA IEREQEKRGN L 

Q53586 in FASTA format

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