NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=NI86/21;
DOI=10.1016/0378-1119(94)90610-6; PubMed=8200543 [NCBI, ExPASy, EBI, Israel, Japan]
de Mot R., Nagy I., Schoofs G., Vanderleyden J.;
"Sequences of the cobalamin biosynthetic genes cobK, cobL and cobM from Rhodococcus sp. NI86/21.";
Gene 143:91-93(1994).

Comments

FUNCTION: Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y.
CATALYTIC ACTIVITY: Precorrin-6B + NADP⁺ = precorrin-6A + NADPH.
PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinic acid a,c-diamide from precorrin-2 (aerobic route): step 6/10 .
SIMILARITY: Belongs to the precorrin-6x reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L21196; AAC37131.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

T46837; T46837.

3D structure databases

ModBase

Q53139.

Family and domain databases

InterPro

IPR003723; Cbl_synth_CobK/CbiJ.
Graphical view of domain structure.

Pfam

PF02571; CbiJ; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00715; precor6x_red; 1.

PROSITE

PS51014; COBK_CBIJ; 1.
PROSITE graphical view of domain structure (profiles).

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cobalamin biosynthesis; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 248`	`248`		`Precorrin-6A reductase.`	`PRO_0000135922`

Sequence information

Length: 248 AA [This is the length of the unprocessed precursor]

Molecular weight: 26142 Da [This is the MW of the unprocessed precursor]

CRC64: 2BA2B2D6810C4623 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTRILILGGT GEARALAAAL ADVPGVEAVS SLAGRVRDPR LPVGDVRIGG FGGADGLAEC 

        70         80         90        100        110        120 
VRAHPVDAIV DATHPFAAQI TRNAADAAHR RGIPLVVLRR PEWSPRPGEH WHGAADLADA 

       130        140        150        160        170        180 
AELLPDLGTR IFLTIGRQGV DAFADLQALW FLIRAIDPPD VAMPPHSTLL LARGPFAVAD 

       190        200        210        220        230        240 
ETALMREHRI DVLVTKNSGG GQTDAKLDAA RALGIPVLMI RRPPLPPATE TVDDVAGAIA 


WVGTLTRR

Q53139 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools