Pyruvate synthase subunit porC
     (EC 1.2.7.1)
     (Pyruvate oxidoreductase gamma chain)
     (POR)
     (Pyruvic-ferredoxin oxidoreductase subunit gamma)
Ketoisovalerate oxidoreductase subunit vorC
     (VOR)
     (EC 1.2.7.7)
     (2-oxoisovalerate oxidoreductase gamma chain)
     (2-oxoisovalerate ferredoxin reductase subunit gamma)

Gene name

	Name:	porG
	OrderedLocusNames:	PF0971

From

Pyrococcus furiosus

[TaxID: 2261]

[HAMAP proteome]

Taxonomy

Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus.

Protein existence

1: Evidence at protein level;

References

[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-28. STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1; PubMed=8550425 [NCBI, ExPASy, EBI, Israel, Japan] Kletzin A., Adams M.W.W.; "Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima."; J. Bacteriol. 178:248-257(1996).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1; Weiss R.B., Dunn D.M., Robb F.T., Brown J.R.; "The complete sequence of the Pyrococcus furiosus genome."; Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
[3]	CHARACTERIZATION. STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1; DOI=10.1016/0167-4838(93)90190-3; PubMed=8380721 [NCBI, ExPASy, EBI, Israel, Japan] Blamey J.M., Adams M.W.W.; "Purification and characterization of pyruvate ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus."; Biochim. Biophys. Acta 1161:19-27(1993).

Comments

CATALYTIC ACTIVITY: Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO₂ + 2 reduced ferredoxin + 2 H⁺.
CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO₂ + 2 reduced ferredoxin + H⁺.
SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X85250; CAA59500.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE010209; AAL81095.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

T45083; T45083.

RefSeq

NP_578700.1; -.

3D structure databases

ModBase

Q51799.

Ontologies

GO:0043807;	Molecular function: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity (inferred from electronic annotation from EC).
GO:0019164;	Molecular function: pyruvate synthase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR011894; PorC_KorC.
IPR002869; Pyrv_Fd/Flavodoxin_OxRdtase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.920.10; Pyrv_Fd/Flavodoxin_OxRdtase; 1.

Pfam

PF01558; POR; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02175; PorC_KorC; 1.

BLOCKS

Q51799.

Genome annotation databases

1468836; -.

AE009950_GR; PF0971.

pfu:PF0971; -.

fig|186497.1.peg.1007; -.

Phylogenomic databases

HOGENOM

Q51799; -.

Genome annotation databases

CMR

Q51799; PF0971.

Other

ProtoNet

Q51799.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Direct protein sequencing; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 185`	`185`		`Pyruvate/ketoisovalerate oxidoreductases common subunit gamma.`	`PRO_0000099914`

Sequence information

Length: 185 AA [This is the length of the unprocessed precursor]

Molecular weight: 20021 Da [This is the MW of the unprocessed precursor]

CRC64: E58743586CE87C13 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MIEVRFHGRG GQGAVTAANI LAEAAFLEGK YVQAFPFFGV ERRGAPVTAF TRIDNKPIRI 

        70         80         90        100        110        120 
KTQIYEPDVV VVLDPSLLDA VDVTAGLKDE GIVIVNTEKS KEEVLEKLKK KPKKLAIVDA 

       130        140        150        160        170        180 
TTIALEILGL PITNTAILGA VAKATGLVKI ESIEEAIKDT FSGELGEKNA RAAREAYEKT 


EVFEL

Q51799 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools