ID   PQQC_METFL              Reviewed;          52 AA.
AC   Q50438;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   04-NOV-2008, entry version 37.
DE   RecName: Full=Pyrroloquinoline-quinone synthase;
DE            EC=1.3.3.11;
DE   AltName: Full=Coenzyme PQQ synthesis protein C;
DE   AltName: Full=Pyrroloquinoline quinone biosynthesis protein C;
DE   Flags: Fragment;
GN   Name=pqqC;
OS   Methylobacillus flagellatum.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Methylophilales;
OC   Methylophilaceae; Methylobacillus.
OX   NCBI_TaxID=405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=96313313; PubMed=8768519; DOI=10.1016/0378-1097(96)00217-0;
RA   Gomelsky M., Biville F., Gasser F., Tsygankov Y.D.;
RT   "Identification and characterization of the pqqDGC gene cluster
RT   involved in pyrroloquinoline quinone production in an obligate
RT   methylotroph Methylobacillus flagellatum.";
RL   FEMS Microbiol. Lett. 141:169-176(1996).
CC   -!- FUNCTION: Ring cyclization and eight-electron oxidation of 3a-(2-
CC       amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-
CC       7,9-dicarboxylic-acid to PQQ (By similarity).
CC   -!- CATALYTIC ACTIVITY: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-
CC       1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O(2) = 4,5-
CC       dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate
CC       + 2 H(2)O(2) + 2 H(2)O.
CC   -!- PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the pqqC family.
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DR   EMBL; L78064; AAB42381.1; -; Genomic_DNA.
DR   GO; GO:0033732; F:pyrroloquinoline-quinone synthase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00654; -; 1.
DR   InterPro; IPR016084; Haem_Oase-like_multi-hlx.
DR   InterPro; IPR004305; TENA/THI4/PQQ_synth_PqqC.
DR   Gene3D; G3DSA:1.20.910.10; Haem_Oase-like_multi-hlx; 1.
DR   Pfam; PF03070; TENA_THI-4; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; PQQ biosynthesis.
FT   CHAIN         1    >52       Pyrroloquinoline-quinone synthase.
FT                                /FTId=PRO_0000219981.
FT   NON_TER      52     52
SQ   SEQUENCE   52 AA;  6365 MW;  3EE6EE2742DBBAE1 CRC64;
     MNAPLTDNIP WTREEFEQKL RDKGRGYHIY HPFHVMMYEG KLTREQLQCW VA
//