[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Larva; NIH - Zebrafish Gene Collection (ZGC) project; Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: Myo-inositol + O₂ = D-glucuronate + H₂O.
COFACTOR: Binds 2 iron ions per subunit (By similarity).
PATHWAY: Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the myo-inositol oxygenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC097218; AAH97218.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001025437.1; -.

UniGene

Dr.90253

3D structure databases

ModBase

Q4V8T0.

Organism-specific databases

ZFIN

ZDB-GENE-050913-113; zgc:114168.

Ontologies

GO:0050113;	Molecular function: inositol oxygenase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR007828; DUF706.
Graphical view of domain structure.

PANTHER

PTHR12588; DUF706; 1.

Pfam

PF05153; DUF706; 1.
Pfam graphical view of domain structure.

BLOCKS

Q4V8T0.

Genome annotation databases

Ensembl

ENSDARG00000002764; Danio rerio. [Contig view]

GeneID

571850; -.

KEGG

dre:571850; -.

Phylogenomic databases

HOGENOM

Q4V8T0; -.

HOVERGEN

Q4V8T0; -.

Other

ProtoNet

Q4V8T0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Iron; Metal-binding; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 278`	`278`	`Inositol oxygenase.`	`PRO_0000079153`
`METAL`	`91 91`		`Iron 1 (By similarity).`
`METAL`	`116 116`		`Iron 1 (By similarity).`
`METAL`	`117 117`		`Iron 1 (By similarity).`
`METAL`	`117 117`		`Iron 2 (By similarity).`
`METAL`	`187 187`		`Iron 2 (By similarity).`
`METAL`	`213 213`		`Iron 2 (By similarity).`
`METAL`	`246 246`		`Iron 1 (By similarity).`

Sequence information

Length: 278 AA [This is the length of the unprocessed precursor]

Molecular weight: 32735 Da [This is the MW of the unprocessed precursor]

CRC64: 77473AF42E647FD0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGPDPSLAYR PECHEKDKTE FRNFENGDLF DRVFNTYKLM HTHQTLDFVK QKHQVWSNCS 

        70         80         90        100        110        120 
HFSLSMMDSI DSLDELVDES DPDVDFPNSF HAFQTAEGIR REHPDKDWFQ LVGLIHDVGK 

       130        140        150        160        170        180 
VMALYSEPQW AVVGDTYPVG CKFQNSIVFR NSTFEGNPDG KNPAPNTEFG IYEPQCGLDK 

       190        200        210        220        230        240 
VLMSWGHDEY LYRVMKFNKC TIPEEGLYMI RFHSFYPWHS NGDYMHLCNE KDQQMLPWVK 

       250        260        270 
EFNKFDLYTK STELPDVERL KPYYQSLIDK YCPGVLQW

Q4V8T0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools