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UniProtKB/Swiss-Prot entry Q4UM06


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NUOB_RICFE
Primary accession number Q4UM06
Secondary accession numbers None
Integrated into Swiss-Prot on May 15, 2007
Sequence was last modified on July 5, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 19)
Name and origin of the protein
Protein name NADH-quinone oxidoreductase subunit B
Synonyms EC 1.6.99.5
NADH dehydrogenase I subunit B
NDH-1 subunit B
Gene name
Name: nuoB
OrderedLocusNames: RF_0566
From
Rickettsia felis (Rickettsia azadi) [TaxID: 42862] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC VR-1525 / URRWXCal2;
DOI=10.1371/journal.pbio.0030248; PubMed=15984913 [NCBI, ExPASy, EBI, Israel, Japan]
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.;
"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite.";
PLoS Biol. 3:1-12(2005).
Comments
  • FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
  • CATALYTIC ACTIVITY: NADH + quinone = NAD+ + quinol.
  • COFACTOR: Binds 1 4Fe-4S cluster (Potential).
  • SIMILARITY: Belongs to the complex I 20 kDa subunit family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000053; AAY61417.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_246582.1; -.
3D structure databases
ModBase Q4UM06.
Enzyme and pathway databases
BioCyc RFEL315456:RF_0566-MON; -.
Family and domain databases
InterPro IPR006138; NADH_DHase_20kDa_su.
IPR014406; NiFe_hyd_3_ssu/Q_oxred_NuoB.
IPR006137; OxRdtase_q6.
Graphical view of domain structure.
PANTHER PTHR11995:SF2; NADH_DH_20kDa; 1.
PTHR11995; NiFe_hyd_3_ssu/Q_oxred_NuoB; 1.
Pfam PF01058; Oxidored_q6; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01957; nuoB_fam; 1.
PROSITE PS01150; COMPLEX1_20K; 1.
BLOCKS Q4UM06.
Genome annotation databases
GeneID 3400345; -.
GenomeReviews CP000053_GR; RF_0566.
KEGG rfe:RF_0566; -.
NMPDR fig|315456.3.peg.400; -.
Phylogenomic databases
HOGENOM Q4UM06; -.
Genome annotation databases
CMR Q4UM06; RF_0566.
Other
ProtoNet Q4UM06.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Quinone.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   174  174     NADH-quinone oxidoreductase subunit B. PRO_0000287852
METAL   47    47        Iron-sulfur (4Fe-4S) (Potential). 
METAL   48    48        Iron-sulfur (4Fe-4S) (Potential). 
METAL   112   112        Iron-sulfur (4Fe-4S) (Potential). 
METAL   142   142        Iron-sulfur (4Fe-4S) (Potential). 
Sequence information
Length: 174 AA [This is the length of the unprocessed precursor] Molecular weight: 19639 Da [This is the MW of the unprocessed precursor] CRC64: 1B89DA83ADCAAA3C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKHSFYQEDE LLNNELSNRG FLLTKVDDVI GWARANSLWP MTFGLACCAV EMMQAAASRY 

        70         80         90        100        110        120 
DMDRFGMLFR PSPRQSDLMI VAGTLTNKMA PALRKVYDQM AEPKWVLSMG SCANGGGYYH 

       130        140        150        160        170 
FSYSVVRGCD RIVPVDVYVP GCPPTAEALI YGLMQLQKKI KRTTGFKYDA RQTH 

Q4UM06 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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