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UniProtKB/Swiss-Prot entry Q4UM05


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NUOA_RICFE
Primary accession number Q4UM05
Secondary accession numbers None
Integrated into Swiss-Prot on January 9, 2007
Sequence was last modified on July 5, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 23)
Name and origin of the protein
Protein name NADH-quinone oxidoreductase subunit A
Synonyms EC 1.6.99.5
NADH dehydrogenase I subunit A
NDH-1 subunit A
Gene name
Name: nuoA
OrderedLocusNames: RF_0567
From
Rickettsia felis (Rickettsia azadi) [TaxID: 42862] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC VR-1525 / URRWXCal2;
DOI=10.1371/journal.pbio.0030248; PubMed=15984913 [NCBI, ExPASy, EBI, Israel, Japan]
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.;
"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite.";
PLoS Biol. 3:1-12(2005).
Comments
  • FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
  • CATALYTIC ACTIVITY: NADH + quinone = NAD+ + quinol.
  • SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
  • SIMILARITY: Belongs to the complex I subunit 3 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000053; AAY61418.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_246583.1; -.
3D structure databases
ModBase Q4UM05.
Enzyme and pathway databases
BioCyc RFEL315456:RF_0567-MON; -.
Ontologies
GO
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR000440; Oxidored_q4.
Graphical view of domain structure.
PANTHER PTHR11058; Oxidored_q4; 1.
Pfam PF00507; Oxidored_q4; 1.
Pfam graphical view of domain structure.
BLOCKS Q4UM05.
Genome annotation databases
GeneID 3400346; -.
GenomeReviews CP000053_GR; RF_0567.
KEGG rfe:RF_0567; -.
NMPDR fig|315456.3.peg.401; -.
Phylogenomic databases
HOGENOM Q4UM05; -.
Genome annotation databases
CMR Q4UM05; RF_0567.
Other
ProtoNet Q4UM05.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Complete proteome; Membrane; NAD; Oxidoreductase; Quinone; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
CHAIN   1   123  123     NADH-quinone oxidoreductase subunit A. PRO_0000271221
TRANSMEM   11    31  21     Potential. 
TRANSMEM   68    88  21     Potential. 
TRANSMEM   93   113  21     Potential. 
Sequence information
Length: 123 AA [This is the length of the unprocessed precursor] Molecular weight: 14309 Da [This is the MW of the unprocessed precursor] CRC64: 6D028874E4F29BA9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLQNSELLQE YLPIAIFFGI ALLVSGLIMI LPNLLSTKKY NKDKLEPYEC GFEPFSDARS 

        70         80         90        100        110        120 
KFDIRFYLVA ILFIIFDLEI AFLVPWAISL NMIGKIGFFS MIFFLFVLTI GFIYEWKKGA 


LDW 

Q4UM05 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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