ID   GPX8_TETNG              Reviewed;         210 AA.
AC   Q4RSM6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-NOV-2008, entry version 24.
DE   RecName: Full=Probable glutathione peroxidase 8;
DE            EC=1.11.1.9;
GN   Name=gpx8; ORFNames=GSTENG00029623001;
OS   Tetraodon nigroviridis (Green puffer).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;
OC   Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes;
OC   Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- CATALYTIC ACTIVITY: 2 glutathione + H(2)O(2) = glutathione
CC       disulfide + 2 H(2)O.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC   -!- CAUTION: Ser-80 is present instead of the conserved Cys/Sec which
CC       is expected to be the active site residue.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CAAE01014999; CAG08606.1; -; Genomic_DNA.
DR   Ensembl; ENSTNIG00000011407; Tetraodon nigroviridis.
DR   NMPDR; fig|99883.3.peg.21216; -.
DR   HOVERGEN; Q4RSM6; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   InterPro; IPR013376; Glut_perox_Gpx7.
DR   InterPro; IPR000889; Glut_peroxidase.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   PANTHER; PTHR11592; Glut_peroxidase; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   TIGRFAMs; TIGR02540; gpx7; 1.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; FALSE_NEG.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; FALSE_NEG.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   3: Inferred from homology;
KW   Membrane; Oxidoreductase; Peroxidase; Transmembrane.
FT   CHAIN         1    210       Probable glutathione peroxidase 8.
FT                                /FTId=PRO_0000317761.
FT   TRANSMEM     21     40       Potential.
SQ   SEQUENCE   210 AA;  23918 MW;  40C021CC4524175C CRC64;
     MEALGGYPTR SSNPKAKKLT VLLSMTVGVG CLLLLQTQLL KPRRPSDFYS FEVKDAKGRT
     VSLEKYRGKA SLVVNVASRS EQTESNYRSL QELHRELGPS HFNVLAFPCA QFGETETGSS
     RDSEAFAKAT YGVTFPFFSR IKIMGSEAEP AFRFLTDSVQ KVPRWNFWKF LVNPEGKVVR
     FWRTDEPMES IRREVTALVR EIILKKRVEL
//