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UniProtKB/Swiss-Prot entry Q4QHG4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GPDA_LEIMA
Primary accession number Q4QHG4
Secondary accession numbers None
Integrated into Swiss-Prot on November 28, 2006
Sequence was last modified on July 19, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 22)
Name and origin of the protein
Protein name Glycerol-3-phosphate dehydrogenase [NAD+], glycosomal
Synonym EC 1.1.1.8
Gene name
Name: GPD
ORFNames: LmjF10.0510
From
Leishmania major [TaxID: 5664] 
Taxonomy Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MHOM/IL/81/Friedlin;
DOI=10.1126/science.1112680; PubMed=16020728 [NCBI, ExPASy, EBI, Israel, Japan]
Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.;
"The genome of the kinetoplastid parasite, Leishmania major.";
Science 309:436-442(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CT005249; CAJ02624.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_001681384.1; -.
3D structure databases
SMR Q4QHG4; 11-358.
ModBase Q4QHG4.
Family and domain databases
InterPro IPR013328; DHase_multihelical.
IPR016040; NAD(P)-bd.
IPR006168; NAD-dep_Gly3P_DHase.
IPR011128; NAD-dep_Gly3P_DHase_N.
IPR006109; NAD_Gly3P_DHase_C.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
PANTHER PTHR11728; NAD_Gly3P_DH; 1.
Pfam PF07479; NAD_Gly3P_dh_C; 1.
PF01210; NAD_Gly3P_dh_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000114; Glycerol-3-P_dh; 1.
PRINTS PR00077; GPDHDRGNASE.
ProDom PD001278; NAD_Gly3P_C; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00957; NAD_G3PDH; 1.
BLOCKS Q4QHG4.
Genome annotation databases
GeneID 5649653; -.
KEGG lma:LmjF10.0510; -.
Phylogenomic databases
HOGENOM Q4QHG4; -.
Other
ProtoNet Q4QHG4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycosome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   367  367     Glycerol-3-phosphate dehydrogenase [NAD+], glycosomal. PRO_0000262291
NP_BIND   23    28  6     NAD (By similarity). 
REGION   275   276  2     Substrate binding (By similarity). 
MOTIF   365   367  3     Microbody targeting signal (Potential). 
ACT_SITE   211   211        Proton acceptor (Potential). 
BINDING   98    98        NAD (By similarity). 
BINDING   126   126        Substrate (By similarity). 
BINDING   158   158        NAD; via amide nitrogen (By similarity). 
BINDING   275   275        NAD (By similarity). 
BINDING   297   297        NAD; via amide nitrogen (By similarity). 
BINDING   301   301        NAD (By similarity). 
Sequence information
Length: 367 AA [This is the length of the unprocessed precursor] Molecular weight: 39299 Da [This is the MW of the unprocessed precursor] CRC64: 49F47113F30B5657 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MISTKRHINT NELLHLSKAV VFGSGAFGTA LAMVLSKKCR EVCVWHIKEE EARLVNEKRE 

        70         80         90        100        110        120 
NDLYLRGVQL ASNIIFTSDV DEAYKGAELI LFVIPTQFLR GFFQKSGGNL IAYAKARQVP 

       130        140        150        160        170        180 
VLVCTKGIER STLKFPAQIV GEFFPSNLLS VLAGPSFAIE VATGVFTCVS VASADINVAR 

       190        200        210        220        230        240 
RLQRIMTTGD RSFVCWATTD TVGCEVASAV KNVLAIGSGV ANGLGMGLNA RAALITRGLL 

       250        260        270        280        290        300 
EIRDLTAALG GDGSAIFGLA GFGDLQLTCS SELSRNFTVG KKLGKGLSLE EIQRTSKAVA 

       310        320        330        340        350        360 
EGVATAEPLV RLAQQLKVTM PLCQQIYEVV YKKKNPRAAI ADLLSCGLQD EGLPPLFKKS 


AATPSKL 

Q4QHG4 in FASTA format

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