[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. He F., Chen Y.; "Isolation of the glycerol-3-phosphate dehydrogenase gene from Candida tropicalis and its application to gene expression in Saccharomyces cerevisiae."; Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: sn-glycerol 3-phosphate + NAD⁺ = glycerone phosphate + NADH.
SIMILARITY: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

DQ064595; AAY63996.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q4PNS1.

Family and domain databases

InterPro

IPR013328; DHase_multihelical.
IPR016040; NAD(P)-bd.
IPR017751; NAD-dep_Gly3P_DH_euk.
IPR006168; NAD-dep_Gly3P_DHase.
IPR011128; NAD-dep_Gly3P_DHase_N.
IPR006109; NAD_Gly3P_DHase_C.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.

PANTHER

PTHR11728; NAD_Gly3P_DH; 1.

Pfam

PF07479; NAD_Gly3P_dh_C; 1.
PF01210; NAD_Gly3P_dh_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000114; Glycerol-3-P_dh; 1.

PRINTS

PR00077; GPDHDRGNASE.

ProDom

PD001278; NAD_Gly3P_C; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00957; NAD_G3PDH; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 391`	`391`	`Glycerol-3-phosphate dehydrogenase [NAD+].`	`PRO_0000138088`
`NP_BIND`	`46 51`	`6`	`NAD (By similarity).`
`REGION`	`315 316`	`2`	`Substrate binding (By similarity).`
`ACT_SITE`	`250 250`		`Proton acceptor (By similarity).`
`BINDING`	`134 134`		`NAD (By similarity).`
`BINDING`	`157 157`		`NAD; via amide nitrogen (By similarity).`
`BINDING`	`157 157`		`Substrate (By similarity).`
`BINDING`	`190 190`		`NAD; via amide nitrogen (By similarity).`
`BINDING`	`315 315`		`NAD (By similarity).`
`BINDING`	`344 344`		`NAD (By similarity).`

Sequence information

Length: 391 AA [This is the length of the unprocessed precursor]

Molecular weight: 42536 Da [This is the MW of the unprocessed precursor]

CRC64: B409DA55F000945D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MCTSANNRLD QLTQILHPEN LLNPTNASHP ESSLRPDHPF KIAVVGSGNW GTTIAKIVSE 

        70         80         90        100        110        120 
NAVARPHLFS HFVNMWVFEE KIDGTNLTEI INTRHENIKY LPGVKLPKNL IAVPDIVKAV 

       130        140        150        160        170        180 
KGADLIVFNL PHQFLPRILK QLKGHVPKTT RAISCLKGLE VNANGCKLLS TVIEEELGIA 

       190        200        210        220        230        240 
CGALSGANLA PEIARGNWSE TTVAYRVPAD YRGPGKDIDK LVLKALFHRP YFHVNVIDDV 

       250        260        270        280        290        300 
AGVSIAGALK NVVALAVGFV EGLGWGDNAK AAVMRVGLLE TIKFAKLFFN DAEIDTFTGE 

       310        320        330        340        350        360 
SAGVADLITT CSGGRNVKVG RYMAETGCAA EEAEKKLLNG QSSQGIVTTK EVHEFLTNVN 

       370        380        390 
KLEEFPLFEA TYQITFGSES IENLPNLLNN Y

Q4PNS1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools