NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.187.21.7292-7308.2005; PubMed=16237012 [NCBI, ExPASy, EBI, Israel, Japan]
Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.;
"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.";
J. Bacteriol. 187:7292-7308(2005).

Comments

FUNCTION: Reduction of activated sulfate into sulfite.
CATALYTIC ACTIVITY: Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.
PATHWAY: Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the PAPS reductase family. CysH subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP006716; BAE03722.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_252328.1; -.

3D structure databases

ModBase

Q4L9F3.

Enzyme and pathway databases

BioCyc

SHAE279808:SH0413-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004604;	Molecular function: phosphoadenylyl-sulfate reductase (thioredoxin) activity (inferred from electronic annotation from HAMAP).
GO:0019379;	Biological process: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00063; -; 1.
PBIL [Tree]

InterPro

IPR011798; APS_reductase.
IPR004511; CysH.
IPR002500; PAPS_reduct.
IPR014729; Rossmann-like_a/b/a_fold.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.

Pfam

PF01507; PAPS_reduct; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02055; APS_reductase; 1.
TIGR00434; cysH; 1.

BLOCKS

Q4L9F3.

Genome annotation databases

3484069; -.

AP006716_GR; SH0413.

sha:SH0413; -.

fig|279808.3.peg.482; -.

Phylogenomic databases

HOGENOM

Q4L9F3; -.

Genome annotation databases

CMR

Q4L9F3; SH0413.

Other

ProtoNet

Q4L9F3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 243`	`243`		`Phosphoadenosine phosphosulfate reductase.`	`PRO_1000008941`

Sequence information

Length: 243 AA [This is the length of the unprocessed precursor]

Molecular weight: 28093 Da [This is the MW of the unprocessed precursor]

CRC64: 27E3DAA32EE97BC4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSVPTITYEN FEGDPFIDSI STDDATKGAY EILEWAYRTY GDSIVYSCSF GAESMVLIDL 

        70         80         90        100        110        120 
IYQIKPDAQI VFLDTDLHFQ ETYDLIDRVK EHFPKLRIEM KKPDLTLEEQ ADKYNPALWK 

       130        140        150        160        170        180 
NNPNQCCYIR KIKPLEEVLG GAVAWVSGLR RDQSPTRANT NFINKDERFK SVKVCPLIYW 

       190        200        210        220        230        240 
TEDEVWDYIK KHDLPYNALH DQHYPSIGCI PCTAPVFDSE DSRAGRWSNF DKTECGLHVA 


DKP

Q4L9F3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools