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UniProtKB/Swiss-Prot entry Q4KLP0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHTK1_RAT
Primary accession number Q4KLP0
Secondary accession numbers None
Integrated into Swiss-Prot on October 23, 2007
Sequence was last modified on August 2, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 20)
Name and origin of the protein
Protein name Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [Precursor]
Synonyms EC 1.2.4.2
Dehydrogenase E1 and transketolase domain-containing protein 1
Gene name
Name: Dhtkd1
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC099075; AAH99075.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001020891.1; -.
UniGene Rn.13539
3D structure databases
ModBase Q4KLP0.
Organism-specific databases
RGD 1308092; Dhtkd1.
Gene expression databases
ArrayExpress Q4KLP0; -.
Family and domain databases
InterPro IPR011603; 2oxoglutarate_DHase_E1.
IPR001017; DHase_E1.
IPR005475; Transketo_Cen_R.
Graphical view of domain structure.
PANTHER PTHR23152; 2oxoglutarate_DH_E1; 1.
Pfam PF00676; E1_dh; 1.
PF02779; Transket_pyr; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000157; Oxoglu_dh_E1; 1.
TIGRFAMs TIGR00239; 2oxo_dh_E1; 1.
BLOCKS Q4KLP0.
Genome annotation databases
Ensembl ENSRNOG00000023587; Rattus norvegicus. [Contig view]
GeneID 361272; -.
KEGG rno:361272; -.
Phylogenomic databases
HOVERGEN Q4KLP0; -.
Other
ProtoNet Q4KLP0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycolysis; Mitochondrion; Oxidoreductase; Thiamine pyrophosphate; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   920        Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial. PRO_0000307939
Sequence information
Length: 920 AA [This is the length of the unprocessed precursor] Molecular weight: 102642 Da [This is the MW of the unprocessed precursor] CRC64: AA4A70E36AA41104 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MASATVAAAG RALRRAVPLL RRSYQTERGV YGYRPRKAGS GEPRGDRARP SVDHGLARLV 

        70         80         90        100        110        120 
TVYCEHGHKA AQINPLFPGQ ALLDTVPEIQ ALVQTLQGPF TTTGLLNMGK EEASLEEVLA 

       130        140        150        160        170        180 
YLNHIYCGPI SIETAQLQSQ EEKDWFARRF EELKKETFTT EERKHLSKLL LESQEFDHFL 

       190        200        210        220        230        240 
ATKFATVKRY GGEGAESMMG FFHELLKLSA YGGITDIIIG MPHRGRLNLL TGLLQLPPEL 

       250        260        270        280        290        300 
MFRKMRGLSE FPENVAAIGD VLSHLTSSVD LDFGAHRPLH VTMLPNPSHL EAINPVAVGK 

       310        320        330        340        350        360 
TRGRQQSQED GDYSPNGSAQ PGDKVICLQV HGDASFCGQG IVLETFTLSN LPHFRIGGSI 

       370        380        390        400        410        420 
HLIVNNQLGY TTPAERGRSS LYSSDIGKLV GCAIIHVNGD SPEEVVRATR LAFEYQRQFR 

       430        440        450        460        470        480 
KDVIIDLLCY RQWGHNELDE PFFTNPVMYK IIRARKSIPD TYAEHLIASG LMTQEEVSDI 

       490        500        510        520        530        540 
KASYYAKLNG HLANVAHYSP PAPHLQARWQ GLVQPAACVT TWDTGVPLEL LRFVGVKSVE 

       550        560        570        580        590        600 
VPEELQLHSH LLKMYVQSRM EKVKNGTNLD WATAETLALG SLLAQGFNVR LSGQDVGRGT 

       610        620        630        640        650        660 
FSQRHAMVVC QNTDDVYIPL NHMDPNQKGF LEVSNSPLSE EAVLGFEYGM SIESPKLLPL 

       670        680        690        700        710        720 
WEAQFGDFFN GAQIIFDTFI SGGEAKWLLQ SGLVILLPHG YDGAGPDHSS CRIERFLQMC 

       730        740        750        760        770        780 
DSAEEGVDSD TVNMFVVHPT TPAQYFHLLR RQMMRNFRKP LIVASPKMLL RYPVAVSTLE 

       790        800        810        820        830        840 
EMAPGTAFKP VIGDSSVDPK NVKTLIFCSG KHFYALLKQR ESLGAKKRDF AIIRLEELCP 

       850        860        870        880        890        900 
FPLDSLQQEM GKYKHVQDII WSQEEPQNMG PWSFVYPRFE KQLACKLRLV SRPPLPAPAV 

       910        920 
GIGTVHQQQH EAILFKTFTS
Q4KLP0 in FASTA format

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