ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q4KLM6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name P3H2_RAT
Primary accession number Q4KLM6
Secondary accession numbers None
Integrated into Swiss-Prot on June 27, 2006
Sequence was last modified on August 2, 2005 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 29)
Name and origin of the protein
Protein name Prolyl 3-hydroxylase 2 [Precursor]
Synonyms EC 1.14.11.7
Leprecan-like protein 1
Gene name
Name: Leprel1
Synonyms: P3h2
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC099107; AAH99107.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001020798.1; -.
UniGene Rn.213595
3D structure databases
ModBase Q4KLM6.
Organism-specific databases
RGD 1304568; Leprel1.
Gene expression databases
ArrayExpress Q4KLM6; -.
GermOnline ENSRNOG00000001925; Rattus norvegicus.
Family and domain databases
InterPro IPR005123; 2OG-FeII_Oase.
IPR000886; ER_targeting_sequence.
IPR006620; Pro_4_hyd_alph.
IPR013105; TPR_2.
IPR013026; TPR_region.
Graphical view of domain structure.
Pfam PF03171; 2OG-FeII_Oxy; 1.
PF07719; TPR_2; 2.
Pfam graphical view of domain structure.
SMART SM00702; P4Hc; 1.
SMART graphical view of domain structure.
PROSITE PS00014; ER_TARGET; 1.
PS50005; TPR; FALSE_NEG.
PS50293; TPR_REGION; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q4KLM6.
Genome annotation databases
Ensembl ENSRNOG00000001925; Rattus norvegicus. [Contig view]
GeneID 288016; -.
KEGG rno:288016; -.
Phylogenomic databases
HOVERGEN Q4KLM6; -.
Other
ProtoNet Q4KLM6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Dioxygenase; Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Iron; Metal-binding; Oxidoreductase; Repeat; Signal; TPR repeat; Vitamin C.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    21  21     Potential. 
CHAIN   22   703  682     Prolyl 3-hydroxylase 2. PRO_0000240358
REPEAT   42    75  34     TPR 1. 
REPEAT   144   177  34     TPR 2. 
REPEAT   205   238  34     TPR 3. 
REPEAT   301   334  34     TPR 4. 
DOMAIN   457   665  209     PKHD. 
MOTIF   700   703  4     Prevents secretion from ER (Potential). 
ACT_SITE   657   657        By similarity. 
METAL   575   575        Iron. 
METAL   577   577        Iron. 
METAL   647   647        Iron. 
CARBOHYD   444   444        N-linked (GlcNAc...) (Potential). 
CARBOHYD   455   455        N-linked (GlcNAc...) (Potential). 
CARBOHYD   544   544        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 703 AA [This is the length of the unprocessed precursor] Molecular weight: 79833 Da [This is the MW of the unprocessed precursor] CRC64: EFE57CEF5F209B63 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRESTWVSLL LLLLLPAPQR GGPQDGRGSP EPEPERGPLQ PFDLLYASGV AAYYSGDYEG 

        70         80         90        100        110        120 
AVRDLEAALR SHRRLRDIRT RCARHCAARR PLAPPGAGPG AELPFFRAVL ERARCSRSCQ 

       130        140        150        160        170        180 
SQRLGGPASR HRVSEDVRSD FQRRVPYNYL QRAYIKLNQL DKAMEAAHTF FMANPEHMEM 

       190        200        210        220        230        240 
QQNIEDYKAT ARVEAPLVDR EAKPHLESYN AGVKHYEADD FEAAIKYFEQ ALREYFNEDM 

       250        260        270        280        290        300 
VCRALCEGPQ RFEEYEYLGS KGSLYEAIAD HYMQVLVCQH ECVRELATRP GRLSPIENFL 

       310        320        330        340        350        360 
PLHYDYLQFA YYRVGEYVKA LECAKAYLMF HPDDQDVLDN VDFYESLLDD STDPASIEAR 

       370        380        390        400        410        420 
EDLTAFVKRH KLEAELIKSA AEGLGFSYSE PNYWISYGGR QDENRVPSGV NMDGAEVHGL 

       430        440        450        460        470        480 
SMGKKSPPKI GRDLREGGPL LYENITFVYN SEQLNGTQRV LLDNVLSEEQ CRELHSVASG 

       490        500        510        520        530        540 
IMLVGDGYRG KTSPHTPNEK FEGATVLKAL KFGYEGRVPL KSARLFYDIS EKARKIVESY 

       550        560        570        580        590        600 
FMLNSTLYFS YTHMVCRTAL SGQQDRRNDL SHPIHADNCL LDPEANECWK EPPAYTFRDY 

       610        620        630        640        650        660 
SALLYMNDDF EGGEFIFTEM DAKTVTASIK PKCGRMISFS SGGENPHGVK AVTRGQRCAV 

       670        680        690        700 
ALWFTLDPLY RELERIQADE VIAILDQEQH GKHGLNINPK DEL
Q4KLM6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by kr flag YPRC Korea Mirror sites: Australia Brazil Canada China Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!