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[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=PH-1 / NRRL 31084;
DOI=10.1126/science.1143708; PubMed=17823352 [NCBI, ExPASy, EBI, Israel, Japan]
Cuomo C.A.,
Gueldener U.,
Xu J.-R.,
Trail F.,
Turgeon B.G.,
Di Pietro A.,
Walton J.D.,
Ma L.-J.,
Baker S.E.,
Rep M.,
Adam G.,
Antoniw J.,
Baldwin T.,
Calvo S.E.,
Chang Y.-L.,
DeCaprio D.,
Gale L.R.,
Gnerre S.,
Goswami R.S., ![]()
Hammond-Kosack K.,
Harris L.J.,
Hilburn K.,
Kennell J.C.,
Kroken S.,
Magnuson J.K.,
Mannhaupt G.,
Mauceli E.W.,
Mewes H.-W.,
Mitterbauer R.,
Muehlbauer G.,
Muensterkoetter M.,
Nelson D.,
O'Donnell K.,
Ouellet T.,
Qi W.,
Quesneville H.,
Roncero M.I.G.,
Seong K.-Y.,
Tetko I.V.,
Urban M.,
Waalwijk C.,
Ward T.J.,
Yao J.,
Birren B.W.,
Kistler H.C.;
"The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.";
Science 317:1400-1402(2007).
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- FUNCTION: Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me (By similarity).
- CATALYTIC ACTIVITY: Acetyl-CoA + histone = CoA + acetylhistone.
- SUBUNIT: Component of the NuA4 histone acetyltransferase complex (By similarity).
- SUBCELLULAR LOCATION: Nucleus (By similarity).
- DOMAIN: The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.
- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 502 AA [This is the length of the unprocessed precursor] |
Molecular weight: 58095 Da [This is the MW of the unprocessed precursor] |
CRC64: 61DCF761F2C3CD43 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAGGTPGGEP TVGSGEPRLK SLATPETIKT GCIAWVEKEG QPRRAEILSI KTTKSGKQFY
70 80 90 100 110 120
CNFDNFNKRL DEWVPVIRLD FTREVEWPNP EKEKPKDPKA KKAPTVQSKK TQPSKKSQKR
130 140 150 160 170 180
PSKREQSTTS EANTPHPWTD FVENQNRQKS ASIGPDGDSQ ARASVDGGET PGGGDEMEVD
190 200 210 220 230 240
ERETEVKREP AEFSREVEIE KLRTSGSMTQ NPTEVSRIRN ISKVQFGRFD LYPWYFSPYP
250 260 270 280 290 300
EIFSQEDVIF ICEFCLSYYG DLKAFTRHRK KCTLQHPPGN ELYRNEEISF FEIDGRRQRT
310 320 330 340 350 360
WCRNLCLLSK MFLDHKTLYY DVDPFLFYVM TVRTEKGCHM VGYFSKEKES ADGYNVACIL
370 380 390 400 410 420
TMPQYQRKGY GRLLIQFSYE LSRIEGKLGS PEKPLSDLGL LSYRQYWSEN ILEFLMGYNE
430 440 450 460 470 480
RDEKVTIEAI STALAMTTQD VEHTLQALRM QVYHKSDHKI VIPEKLIEQR EKTKLKRKRT
490 500
VDPTKIQWKP PVFTASSRTW GW
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Q4IEV4 in FASTA format |
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