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[1]
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NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, AND TISSUE SPECIFICITY.
TISSUE=Fetal brain;
DOI=10.1021/bi962209o; PubMed=8909283 [NCBI, ExPASy, EBI, Israel, Japan]
Hsu D.S.,
Zhao X.,
Zhao S.,
Kazantsev A.,
Wang R.-P.,
Todo T.,
Wei Y.-F.,
Sancar A.;
"Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins.";
Biochemistry 35:13871-13877(1996).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-593.
TISSUE=Brain;
DOI=10.1093/dnares/5.3.169; PubMed=9734811 [NCBI, ExPASy, EBI, Israel, Japan]
Ishikawa K.,
Nagase T.,
Suyama M.,
Miyajima N.,
Tanaka A.,
Kotani H.,
Nomura N.,
Ohara O.;
"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.";
DNA Res. 5:169-176(1998).
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[4]
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TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
DOI=10.1093/nar/26.22.5086; PubMed=9801304 [NCBI, ExPASy, EBI, Israel, Japan]
Kobayashi K.,
Kanno S.,
Smit B.,
van der Horst G.T.J.,
Takao M.,
Yasui A.;
"Characterization of photolyase/blue-light receptor homologs in mouse and human cells.";
Nucleic Acids Res. 26:5086-5092(1998).
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[5]
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FUNCTION.
DOI=10.1126/science.286.5440.768; PubMed=10531061 [NCBI, ExPASy, EBI, Israel, Japan]
Griffin E.A. Jr.,
Staknis D.,
Weitz C.J.;
"Light-independent role of CRY1 and CRY2 in the mammalian circadian clock.";
Science 286:768-771(1999).
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- FUNCTION: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.
- COFACTOR: Binds 1 FAD per subunit (By similarity).
- COFACTOR: Binds 1 5,10-methenyltetrahydrofolate non-covalently per subunit (By similarity).
- SUBUNIT: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with PER1 and PER2 C-terminal domains. Interaction with PER2 inhibits its ubiquitination and vice versa. Interacts with NFIL3 (By similarity).
- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL.
- TISSUE SPECIFICITY: Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, sketal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest levels in heart and skeletal muscle.
- PTM: Phosphorylation on Ser-266 by MAPK is important for the inhibition of CLOCK-ARNTL-mediated transcriptional activity. Phosphorylation by CSKNE requires interaction with PER1 or PER2.
- SIMILARITY: Belongs to the DNA photolyase class-1 family.
- SIMILARITY: Contains 1 DNA photolyase domain.
- WEB RESOURCE: Name=Wikipedia; Note=Cryptochrome entry; URL="http://en.wikipedia.org/wiki/Cryptochrome";.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 593 AA [This is the length of the unprocessed precursor] |
Molecular weight: 66947 Da [This is the MW of the unprocessed precursor] |
CRC64: BF380424092BEBFB [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAATVATAAA VAPAPAPGTD SASSVHWFRK GLRLHDNPAL LAAVRGARCV RCVYILDPWF
70 80 90 100 110 120
AASSSVGINR WRFLLQSLED LDTSLRKLNS RLFVVRGQPA DVFPRLFKEW GVTRLTFEYD
130 140 150 160 170 180
SEPFGKERDA AIMKMAKEAG VEVVTENSHT LYDLDRIIEL NGQKPPLTYK RFQAIISRME
190 200 210 220 230 240
LPKKPVGLVT SQQMESCRAE IQENHDETYG VPSLEELGFP TEGLGPAVWQ GGETEALARL
250 260 270 280 290 300
DKHLERKAWV ANYERPRMNA NSLLASPTGL SPYLRFGCLS CRLFYYRLWD LYKKVKRNST
310 320 330 340 350 360
PPLSLFGQLL WREFFYTAAT NNPRFDRMEG NPICIQIPWD RNPEALAKWA EGKTGFPWID
370 380 390 400 410 420
AIMTQLRQEG WIHHLARHAV ACFLTRGDLW VSWESGVRVF DELLLDADFS VNAGSWMWLS
430 440 450 460 470 480
CSAFFQQFFH CYCPVGFGRR TDPSGDYIRR YLPKLKAFPS RYIYEPWNAP ESIQKAAKCI
490 500 510 520 530 540
IGVDYPRPIV NHAETSRLNI ERMKQIYQQL SRYRGLCLLA SVPSCVEDLS HPVAEPSSSQ
550 560 570 580 590
AGSMSSAGPR PLPSGPASPK RKLEAAEEPP GEELSKRARV AELPTPELPS KDA
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Q49AN0 in FASTA format |
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