NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Possesses significant protein thiol-disulfide oxidase activity (By similarity).
CATALYTIC ACTIVITY: 2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (By similarity).
SIMILARITY: Contains 1 thioredoxin domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC100255; AAI00256.1; ALT_INIT; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

UniGene

Rn.5953

3D structure databases

SMR

Q498E0; 28-161.

ModBase

Q498E0.

Protein-protein interaction databases

IntAct

Q498E0; -.

Organism-specific databases

RGD

1305960; Txndc12.

Gene expression databases

ArrayExpress

Q498E0; -.

GermOnline

ENSRNOG00000008090; Rattus norvegicus.

Ontologies

GO:0005788;	Cellular component: endoplasmic reticulum lumen (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

InterPro

IPR000886; ER_targeting_sequence.
IPR006662; Thioredoxin-like.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.30.10; Thioredoxin_fold; 1.

PROSITE

PS00014; ER_TARGET; 1.
PS00194; THIOREDOXIN_1; 1.
PS51352; THIOREDOXIN_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q498E0.

Genome annotation databases

Ensembl

ENSRNOG00000008090; Rattus norvegicus. [Contig view]

NMPDR

fig|10116.3.peg.23626; -.

Phylogenomic databases

HOVERGEN

Q498E0; -.

Other

ProtoNet

Q498E0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Endoplasmic reticulum; Glycoprotein; Oxidoreductase; Redox-active center; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 24`	`24`	`By similarity.`
`CHAIN`	`25 170`	`146`	`Thioredoxin domain-containing protein 12.`	`PRO_0000233975`
`MOTIF`	`167 170`	`4`	`Prevents secretion from ER (Potential).`
`CARBOHYD`	`128 128`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`64 67`		`Redox-active (Potential).`

Sequence information

Length: 170 AA [This is the length of the unprocessed precursor]

Molecular weight: 19019 Da [This is the MW of the unprocessed precursor]

CRC64: 444B6C9BE12C5E44 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSLRFGATCL LSFSFLLLIT SSDGRTGLGK GFGDHIHWRT LEDGKKEAAA SGLPLMVIIH 

        70         80         90        100        110        120 
KSWCGACKAL KPKFAESTEI SELSHNFVMV NLEDEEEPRD EDFSPDGGYI PRILFLDPSG 

       130        140        150        160        170 
KVRPEIINES GNPSYKYFYV SAEQVVQGMK EAQVRLTGDA FREKHFQDEL

Q498E0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools