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UniProtKB/Swiss-Prot entry Q493R1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU3_BLOPB
Primary accession number Q493R1
Secondary accession numbers None
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on September 13, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 24)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase
IMDH
3-IPM-DH
Gene name
Name: leuB
OrderedLocusNames: BPEN_136
From
Blochmannia pennsylvanicus (strain BPEN) [TaxID: 291272] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; ant endosymbionts; Candidatus Blochmannia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1101/gr.3771305; PubMed=16077009 [NCBI, ExPASy, EBI, Israel, Japan]
Degnan P.H., Lazarus A.B., Wernegreen J.J.;
"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects.";
Genome Res. 15:1023-1033(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000016; AAZ40776.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_277649.1; -.
3D structure databases
ModBase Q493R1.
Enzyme and pathway databases
BioCyc CBLO291272:BPEN_136-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01033; -; 1.
PBIL [Tree]
InterPro IPR004429; 3-isopropylmalate_DHase.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF13; IPMDH; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00169; leuB; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q493R1.
Genome annotation databases
GeneID 3563104; -.
GenomeReviews CP000016_GR; BPEN_136.
KEGG bpn:BPEN_136; -.
Phylogenomic databases
HOGENOM Q493R1; -.
Genome annotation databases
CMR Q493R1; BPEN_136.
Other
ProtoNet Q493R1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   366  366     3-isopropylmalate dehydrogenase. PRO_0000083648
NP_BIND   78    91  14     NAD (By similarity). 
NP_BIND   285   297  13     NAD (By similarity). 
METAL   227   227        Magnesium or manganese (By similarity). 
METAL   251   251        Magnesium or manganese (By similarity). 
METAL   255   255        Magnesium or manganese (By similarity). 
BINDING   99    99        Substrate (By similarity). 
BINDING   109   109        Substrate (By similarity). 
BINDING   138   138        Substrate (By similarity). 
BINDING   227   227        Substrate (By similarity). 
SITE   145   145  1     Important for catalysis (By similarity). 
SITE   195   195  1     Important for catalysis (By similarity). 
Sequence information
Length: 366 AA [This is the length of the unprocessed precursor] Molecular weight: 40664 Da [This is the MW of the unprocessed precursor] CRC64: F93A9E60886990C9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNNNYHIAVL PGDGIGPETT RQVYKILNVI KKQFQINIVT TEHKIGGDAI NSEGTPFPKS 

        70         80         90        100        110        120 
TLKYCEQSNA ILFGAVGGPQ WTHLKGSESP EQGALLALRK HFNLFANLRP IYLADELKEL 

       130        140        150        160        170        180 
SPLNINMIPN GIDIIFVREL TGGIYFGQPK GRSGTGLNEY AFDTAVYHRF EIERIANIAF 

       190        200        210        220        230        240 
KLAQKRRKRV SSIDKANVLH TSMLWREVVS HLAKNYPDVE LEHLYIDNAS MQLINNPSKF 

       250        260        270        280        290        300 
DIILCPNLFG DILSDECAMI SGSIGMLPSA SINEHNFGLY EPAGGSAPDI AEKNIANPIA 

       310        320        330        340        350        360 
HILSIALLFR YSLKLDHIAI KIEKAVSQAL MLGYRTIDIA KKHEKSISTN EMGDIIAALI 


KNEREK
Q493R1 in FASTA format

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