ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q49163

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name ACDA2_METMA
Primary accession number Q49163
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on January 23, 2007 (Sequence version 4)
Annotations were last modified on    September 2, 2008 (Entry version 65)
Name and origin of the protein
Protein name Acetyl-CoA decarbonylase/synthase complex subunit alpha 2
Synonyms ACDS complex subunit alpha 2
EC 1.2.99.2
ACDS complex carbon monoxide dehydrogenase 2
ACDS CODH 2
Gene name
Name: cdhA2
OrderedLocusNames: MM_0684
From
Methanosarcina mazei (Methanosarcina frisia) [TaxID: 2209] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-12 AND 560-564.
STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88;
DOI=10.1074/jbc.271.24.14256; PubMed=8662887 [NCBI, ExPASy, EBI, Israel, Japan]
Eggen R.I.L., van Kranenburg R., Vriesema A.J.M., Geerling A.C.M., Verhagen M.F.J.M., Hagen W.R., de Vos W.M.;
"Carbon monoxide dehydrogenase from Methanosarcina frisia Go1. Characterization of the enzyme and the regulated expression of two operon-like cdh gene clusters.";
J. Biol. Chem. 271:14256-14263(1996).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88;
PubMed=12125824 [NCBI, ExPASy, EBI, Israel, Japan]
Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.;
"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea.";
J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L26486; AAC37042.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE008384; AAM30380.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_632708.1; -.
3D structure databases
ModBase Q49163.
Enzyme and pathway databases
BioCyc MMAZ192952:MM0684-MON; -.
Ontologies
GO
GO:0018492; Molecular function: carbon-monoxide dehydrogenase (acceptor) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01137; -; 1.
PBIL [Tree]
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR004460; CO_DHase/Ac-CoA_synth_asu.
IPR016101; CO_DHase_a-bundle.
IPR004137; Prismane.
IPR016099; Prismane-like_a/b-sand.
Graphical view of domain structure.
Gene3D G3DSA:1.20.1270.30; CO_DH_a-bundle; 1.
G3DSA:3.40.50.2030; Prismane-like_a/b-sand; 2.
Pfam PF00037; Fer4; 1.
PF03063; Prismane; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00314; cdhA; 1.
PROSITE PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 2.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q49163.
Genome annotation databases
GeneID 1479026; -.
GenomeReviews AE008384_GR; MM_0684.
KEGG mma:MM_0684; -.
NMPDR fig|192952.1.peg.684; -.
Phylogenomic databases
HOGENOM Q49163; -.
Genome annotation databases
CMR Q49163; MM_0684.
Other
ProtoNet Q49163.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Methanogenesis; Nickel; Oxidoreductase; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   807  806     Acetyl-CoA decarbonylase/synthase complex subunit alpha 2. PRO_0000155081
DOMAIN   407   436  30     4Fe-4S ferredoxin-type 1. 
DOMAIN   446   475  30     4Fe-4S ferredoxin-type 2. 
METAL   73    73        Iron-sulfur 1 (4Fe-4S); shared with dimeric partner (By similarity). 
METAL   76    76        Iron-sulfur 1 (4Fe-4S); shared with dimeric partner (By similarity). 
METAL   77    77        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   79    79        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   84    84        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   94    94        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   250   250        Nickel-iron-sulfur (By similarity). 
METAL   278   278        Nickel-iron-sulfur (By similarity). 
METAL   323   323        Nickel-iron-sulfur (By similarity). 
METAL   417   417        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   420   420        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   423   423        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   427   427        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   455   455        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   458   458        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   461   461        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   465   465        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   523   523        Nickel-iron-sulfur (By similarity). 
METAL   552   552        Nickel-iron-sulfur (By similarity). 
METAL   587   587        Nickel-iron-sulfur (By similarity). 
CONFLICT   57    57        W -> R (in Ref. 1; AAC37042). 
Sequence information
Length: 807 AA [This is the length of the unprocessed precursor] Molecular weight: 88508 Da [This is the MW of the unprocessed precursor] CRC64: E00F628DC63C52BD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSKLTTGSFS IEDLESVQIT INNIVGAAKE AAEEKAKELV KAGPTLFPGL ESYRDDWNFK 

        70         80         90        100        110        120 
LLDRYEPVVT PMCDQCCYCT YGPCDLSGNK RGACGIDMMG HNGREFFLRV ITGTACHAAH 

       130        140        150        160        170        180 
GRHLLDHLIE TFGEDLPLNL GQSNVLTPNI TISTGLSPKN LGEVKPAMEF VEEQLTQLLA 

       190        200        210        220        230        240 
TVHAGQESAE IDYDSKALFS GSLDHVGMEI SDVVQVAAYD FPKADPEAPL IEIGMGTIDK 

       250        260        270        280        290        300 
SKPFLCVIGH NVGGVTYMMD YMEENNLTDK MEIAGLCCTA IDLTRYKEAD RRPPYAKVIG 

       310        320        330        340        350        360 
SMAKELKVIR SGMPDVIVVD EQCVRGDIVP EAQKLKIPVI ASNAKIMFGL PNRTDADVNE 

       370        380        390        400        410        420 
TIEELKSGAI PGCVMLDYEK LGELCIRLTM EMAPIRDASG ITAIPTDEEL ANWVAKCADC 

       430        440        450        460        470        480 
GACLIACPEE LDIPEAMGFA KEGDYSYLEG LHDICIGCRR CEQVCKKEIP ILNIIEKVSQ 

       490        500        510        520        530        540 
KQIAEEKGWM RAGRGQVSDA EIRAEGLNLV MGTTPGIIAI IGCPNYAEGT KDVYYIAEEF 

       550        560        570        580        590        600 
LKRNFIVVTT GCGAMDIGMF KDDDGKTLYE RYPGGFQCGG LVNIGSCVSN AHITGAAEKV 

       610        620        630        640        650        660 
AAIFAQRTLE GNLAEIADYI LNRVGACGLA WGAFSQKASS IGTGCNILGI PAVLGPHSSK 

       670        680        690        700        710        720 
YRRALIAKTY EEDKWKVYDA RNGQEMPIPP APEFLLTTAE TWQEAIPMMA KACIRPSDNS 

       730        740        750        760        770        780 
MGRAIKLTHW MELHKKYLGG SEPEDWWKFV RNEADLPLAN REALLKKLEA ERGWEIDWKK 

       790        800 
KKIISGPKIK FDVSAQPTNL KRLCKEA
Q49163 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by kr flag YPRC Korea Mirror sites: Australia Brazil Canada China Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!