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UniProtKB/Swiss-Prot entry Q49161

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACDA1_METMA
Primary accession number Q49161
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    September 2, 2008 (Entry version 65)
Name and origin of the protein
Protein name Acetyl-CoA decarbonylase/synthase complex subunit alpha 1
Synonyms ACDS complex subunit alpha 1
EC 1.2.99.2
ACDS complex carbon monoxide dehydrogenase 1
ACDS CODH 1
Gene name
Name: cdhA1
OrderedLocusNames: MM_2089
From
Methanosarcina mazei (Methanosarcina frisia) [TaxID: 2209] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-12.
STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88;
DOI=10.1074/jbc.271.24.14256; PubMed=8662887 [NCBI, ExPASy, EBI, Israel, Japan]
Eggen R.I.L., van Kranenburg R., Vriesema A.J.M., Geerling A.C.M., Verhagen M.F.J.M., Hagen W.R., de Vos W.M.;
"Carbon monoxide dehydrogenase from Methanosarcina frisia Go1. Characterization of the enzyme and the regulated expression of two operon-like cdh gene clusters.";
J. Biol. Chem. 271:14256-14263(1996).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88;
PubMed=12125824 [NCBI, ExPASy, EBI, Israel, Japan]
Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.;
"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea.";
J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L26487; AAC37044.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE008384; AAM31785.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_634113.1; -.
3D structure databases
HSSP P00193; 1DUR. [HSSP ENTRY / PDB]
ModBase Q49161.
Enzyme and pathway databases
BioCyc MMAZ192952:MM2089-MON; -.
Ontologies
GO
GO:0018492; Molecular function: carbon-monoxide dehydrogenase (acceptor) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01137; -; 1.
PBIL [Tree]
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR004460; CO_DHase/Ac-CoA_synth_asu.
IPR016101; CO_DHase_a-bundle.
IPR004137; Prismane.
IPR016099; Prismane-like_a/b-sand.
Graphical view of domain structure.
Gene3D G3DSA:1.20.1270.30; CO_DH_a-bundle; 1.
G3DSA:3.40.50.2030; Prismane-like_a/b-sand; 2.
Pfam PF00037; Fer4; 2.
PF03063; Prismane; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00314; cdhA; 1.
PROSITE PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 2.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q49161.
Genome annotation databases
GeneID 1480431; -.
GenomeReviews AE008384_GR; MM_2089.
KEGG mma:MM_2089; -.
NMPDR fig|192952.1.peg.2089; -.
Phylogenomic databases
HOGENOM Q49161; -.
Genome annotation databases
CMR Q49161; MM_2089.
Other
ProtoNet Q49161.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Methanogenesis; Nickel; Oxidoreductase; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   806  805     Acetyl-CoA decarbonylase/synthase complex subunit alpha 1. PRO_0000155080
DOMAIN   406   436  31     4Fe-4S ferredoxin-type 1. 
DOMAIN   445   475  31     4Fe-4S ferredoxin-type 2. 
METAL   73    73        Iron-sulfur 1 (4Fe-4S); shared with dimeric partner (By similarity). 
METAL   76    76        Iron-sulfur 1 (4Fe-4S); shared with dimeric partner (By similarity). 
METAL   77    77        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   79    79        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   84    84        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   94    94        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   250   250        Nickel-iron-sulfur (By similarity). 
METAL   278   278        Nickel-iron-sulfur (By similarity). 
METAL   323   323        Nickel-iron-sulfur (By similarity). 
METAL   417   417        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   420   420        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   423   423        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   427   427        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   455   455        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   458   458        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   461   461        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   465   465        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   523   523        Nickel-iron-sulfur (By similarity). 
METAL   552   552        Nickel-iron-sulfur (By similarity). 
METAL   587   587        Nickel-iron-sulfur (By similarity). 
Sequence information
Length: 806 AA [This is the length of the unprocessed precursor] Molecular weight: 88583 Da [This is the MW of the unprocessed precursor] CRC64: 8A6EE054FBE778AF [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSKLTTGSFS IEDLESVQIT INNIVGAAKE AAEEKTKELG HMGPTPFPGL ETYRDDWNLK 

        70         80         90        100        110        120 
LLDRYEPVVT PMCDQCCYCT YGPCDLSNNK RGACGIDMLG HNGREFFLRV ITGTACHAAH 

       130        140        150        160        170        180 
GRHLLDHLIE VFGEELPLNL GQSDVLTPNI TITTGQRPQT LGEIKPAMEH VEEQLTQLLA 

       190        200        210        220        230        240 
TVHAGQESAE IDYDSKALFS GSLDHVGMEI SDIVQIAALD FPKADPEAPL IEMGMGTIDK 

       250        260        270        280        290        300 
DKPFLCVIGH NVGGVTYMMD YMEEHELTDK VELGGLCCTA IDLTRYKEAD RRPPYTKVVG 

       310        320        330        340        350        360 
SMSKELKIIR SGMPDVIVVD EQCVRGDIVP EAQKLKIPVI ASNAKIMYGL PNRTDAGVEE 

       370        380        390        400        410        420 
TIEELKSGAI PGAVILDYEK LGEISVRLAQ EMHPIREAAG VREIPSDEQL KEWVDKCADC 

       430        440        450        460        470        480 
GACYLACPIE LDIPEAMKFA KQGDFSYLED LHDACIGCRR CEQVCKKEIP ILSVIEKASQ 

       490        500        510        520        530        540 
KIIAEEKGWM RAGRGQVSDA EIRAEGLNLV MGTTPGIIAI IGCPNYSDCA KAVYYIAEEF 

       550        560        570        580        590        600 
LKRNYIVVGT GCGSMDMGMY KDEDGKTLYE RFPGGFQSGG LVNIGSCVSN AHITGAAQKV 

       610        620        630        640        650        660 
AGIFGGRTME GNLAEIADYV LNRVGACGLA WGAFSQKASS IGTGCNIYGI PAVLGAHSSK 

       670        680        690        700        710        720 
YRRALIAKNY DESKWKVYDA RNGEEMPIPP APEFLLTTAE TWQEAIPMMA KACLRPSDNS 

       730        740        750        760        770        780 
LGRSIKLTHW MELHDKYIGG LPEDWWKFIR TEADLPLAKR ADLMKKLEAE RGWEIDWKKK 

       790        800 
KIISGPKIKF DVSAQPTNLK RLCKGA
Q49161 in FASTA format

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