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UniProtKB/Swiss-Prot entry Q47741

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRDB_ENTFA
Primary accession number Q47741
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on April 23, 2003 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 67)
Name and origin of the protein
Protein name Dihydroorotate dehydrogenase B, catalytic subunit
Synonyms EC 1.3.3.1
Dihydroorotate oxidase B
DHOdehase B
DHODase B
DHOD B
Gene name
Name: pyrDB
Synonyms: pyrD, pyrD-2
OrderedLocusNames: EF_1714
From
Enterococcus faecalis (Streptococcus faecalis) [TaxID: 1351] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Enterococcaceae; Enterococcus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 47077 / OG1RF;
PubMed=7592480 [NCBI, ExPASy, EBI, Israel, Japan]
Li X., Weinstock G.M., Murray B.E.;
"Generation of auxotrophic mutants of Enterococcus faecalis.";
J. Bacteriol. 177:6866-6873(1995).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=V583 / ATCC 700802;
DOI=10.1126/science.1080613; PubMed=12663927 [NCBI, ExPASy, EBI, Israel, Japan]
Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C., Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M., Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
"Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.";
Science 299:2071-2074(2003).
[3]
 CHARACTERIZATION.
STRAIN=ATCC 29212 / DSM 2570;
DOI=10.1021/bi990674q; PubMed=10529184 [NCBI, ExPASy, EBI, Israel, Japan]
Marcinkeviciene J., Tinney L.M., Wang K.H., Rogers M.J., Copeland R.A.;
"Dihydroorotate dehydrogenase B of Enterococcus faecalis. Characterization and insights into chemical mechanism.";
Biochemistry 38:13129-13137(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U24692; AAA67066.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE016830; AAO81490.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_815420.1; -.
3D structure databases
HSSP P54322; 1EP2. [HSSP ENTRY / PDB]
SMR Q47741; 4-309.
ModBase Q47741.
Enzyme and pathway databases
BioCyc EFAE226185:EF_1714-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004158; Molecular function: dihydroorotate oxidase activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00224; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR012135; DHO_DHase_1_2.
IPR005720; DHO_DHase_1_core.
IPR001295; Dihydroorotate_DHase_core.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF01180; DHO_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000164; DHO_oxidase; 1.
TIGRFAMs TIGR01037; pyrD_sub1_fam; 1.
PROSITE PS00911; DHODEHASE_1; 1.
PS00912; DHODEHASE_2; 1.
BLOCKS Q47741.
Genome annotation databases
GeneID 1200606; -.
GenomeReviews AE016830_GR; EF_1714.
KEGG efa:EF1714; -.
NMPDR fig|226185.1.peg.1605; -.
TIGR EF_1714; -.
Phylogenomic databases
HOGENOM Q47741; -.
Other
ProtoNet Q47741.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Flavoprotein; FMN; Oxidoreductase; Pyrimidine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   312  312     Dihydroorotate dehydrogenase B, catalytic subunit. PRO_0000148391
ACT_SITE   133   133        Nucleophile (By similarity). 
CONFLICT   81    81        E -> D (in Ref. 1; AAA67066). 
Sequence information
Length: 312 AA [This is the length of the unprocessed precursor] Molecular weight: 33093 Da [This is the MW of the unprocessed precursor] CRC64: B97956521B85541F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MMKNPLAVSI PGLTLKNPII PASGCFGFGE EYANYYDLDQ LGSIMIKATT PQARYGNPTP 

        70         80         90        100        110        120 
RVAETPSGML NAIGLQNPGL EVVMQEKLPK LEKYPNLPII ANVAGACEED YVAVCAKIGQ 

       130        140        150        160        170        180 
APNVKAIELN ISCPNVKHGG IAFGTDPEVA FQLTQAVKKV ASVPIYVKLS PNVTDIVPIA 

       190        200        210        220        230        240 
QAIEAGGADG FSMINTLLGM RIDLKTRKPI LANQTGGLSG PAIKPVAIRL IRQVASVSQL 

       250        260        270        280        290        300 
PIIGMGGVQT VDDVLEMFMA GASAVGVGTA NFTDPYICPK LIDGLPKRME ELGIESLEQL 

       310 
IKEVREGQQN AR
Q47741 in FASTA format

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