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UniProtKB/Swiss-Prot entry Q46N53

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX2_RALEJ
Primary accession number Q46N53
Secondary accession numbers None
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on September 13, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 26)
Name and origin of the protein
Protein name Histidinol dehydrogenase 2
Synonyms HDH 2
EC 1.1.1.23
Gene name
Name: hisD2
OrderedLocusNames: Reut_C6092
From
Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [TaxID: 264198] [HAMAP proteome]
Encoded on Plasmid megaplasmid Reut.
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Cupriavidus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Vergez L., Larimer F., Land M., Lykidis A., Richardson P.;
"Complete sequence of a megaplasmid of Ralstonia eutropha JMP134.";
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000092; AAZ65418.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_293275.1; -.
3D structure databases
ModBase Q46N53.
Enzyme and pathway databases
BioCyc REUT264198:REUT_C6092-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q46N53.
Genome annotation databases
GeneID 3607398; -.
GenomeReviews CP000092_GR; Reut_C6092.
KEGG reu:Reut_C6092; -.
NMPDR fig|264198.3.peg.6; -.
Phylogenomic databases
HOGENOM Q46N53; -.
Genome annotation databases
CMR Q46N53; Reut_C6092.
Other
ProtoNet Q46N53.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Plasmid; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   436  436     Histidinol dehydrogenase 2. PRO_0000135827
ACT_SITE   318   318        Proton acceptor (By similarity). 
ACT_SITE   319   319        Proton acceptor (By similarity). 
METAL   248   248        Zinc (By similarity). 
METAL   251   251        Zinc (By similarity). 
METAL   352   352        Zinc (By similarity). 
METAL   411   411        Zinc (By similarity). 
BINDING   118   118        NAD (By similarity). 
BINDING   180   180        NAD (By similarity). 
BINDING   203   203        NAD (By similarity). 
BINDING   226   226        Substrate (By similarity). 
BINDING   248   248        Substrate (By similarity). 
BINDING   251   251        Substrate (By similarity). 
BINDING   319   319        Substrate (By similarity). 
BINDING   352   352        Substrate (By similarity). 
BINDING   406   406        Substrate (By similarity). 
BINDING   411   411        Substrate (By similarity). 
Sequence information
Length: 436 AA [This is the length of the unprocessed precursor] Molecular weight: 46881 Da [This is the MW of the unprocessed precursor] CRC64: E505337929A7046C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MISYLKKAEK TPQTETATAQ KVVTEMLAEI QARGKDAVRQ YAKQLDGWSG DIVLTPDQIR 

        70         80         90        100        110        120 
EQTKDVPAGV RADIDFAIRQ VTDFALAQRE SLKEFSVELH PGVTAGQRVL PVNVVGCYAP 

       130        140        150        160        170        180 
AGRYAHIASA YMGVATAKAA GVKTVVACSS PFRGQGIHPH VLYAFQAAGA DVIMALGGVQ 

       190        200        210        220        230        240 
AIASMAYGLF TGKPADVVVG PGNKFVAEAK RSLYGQVGID VFAGPSEVAV IADETADPAI 

       250        260        270        280        290        300 
VASDLVGQAE HGHESPAWLF TTSRDLADRV MALVPELIAK LPPTARDAAT AAWRDYGEVI 

       310        320        330        340        350        360 
LCGTREEVVE ISDRYASEHL EVHTADLDWW LANLTCYGSL FLGEETTVAF GDKTSGPNHV 

       370        380        390        400        410        420 
LPTKGAARYS GGLSVHKFMK TLTWQQMTRE ATRQIGQVTA RISRLEGMEA HARTADDRMA 

       430 
KYFPNASFEM GTPVEV
Q46N53 in FASTA format

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